Historique
Périodique
A pilot study to assess the impact of naltrexone implant on accidental opiate overdose in "high-risk" adolescent heroin users
(Une étude pilote d'évaluation de l'impact d'implant de naltrexone sur les overdoses accidentelles aux opiacés chez des adolescents usagers à haut risque d'héroïne.)
Auteur(s) :
HULSE, G. K. ;
TAIT, R. J.
Année
2003
Page(s) :
337-342
Langue(s) :
Anglais
Refs biblio. :
17
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
NALTREXONE
;
OPIACES
;
SURDOSE
;
REDUCTION DES RISQUES ET DES DOMMAGES
;
VOIE SOUSCUTANEE
;
EFFICACITE
;
ETUDE RETROSPECTIVE
Thésaurus géographique
AUSTRALIE
Note générale :
Addiction Biology, 2003, 8, (3), 337-342
Note de contenu :
fig. ; tabl.
Résumé :
ENGLISH :
Morbidity and mortality rates for regular heroin users are much greater than those observed in the general population. In `high-risk' heroin users implantable naltrexone has been used under Commonwealth Therapeutic Goods Administration Compassionate guidelines in Western Australia since August 2000. This pilot study compared the frequency of accidental opiate overdose and other morbidity resulting in hospital presentations in eight `high-risk' dependent heroin using adolescents pre- and post-naltrexone implant treatment. We reviewed the hospital medical records retrospectively for the participants across the four public hospitals in Perth. The review period was September 1999-October 2002. The eight adolescents (aged 15-19 years) initially underwent naltrexone implant treatment between September 2000 and September 2001. The data indicated a dramatic reduction in opiate overdose post-implantable naltrexone treatment, with a smaller reduction in opiate overdose during oral naltrexone treatment compared to the pre-ora/implant period. Implant treatment in the high-risk heroin user may provide an important prophylaxis against mortality associated with accidental opiate overdose. These encouraging findings now require validation using a larger cohort over art extended period. (Review' s abstract)
Affiliation :
Univ. School Psychiatry, QE I Med. Ctre, ("D" Block), Nedlands, WA 6009. E-mail :ghulsecyllene.uwa.edu.au
Australie. Australia.
Australie. Australia.