Historique
Périodique
Effects of buspirone in withdrawal from opiates
(Effets du buspirone dans le traitement des symptômes de manque aux opiacés.)
Auteur(s) :
ROSE, J. S. ;
BRANCHEY M. ;
WALLACH, L. ;
BUYDENS-BRANCHEY L.
Année
2003
Page(s) :
253-259
Langue(s) :
Anglais
Refs biblio. :
9
Domaine :
Drogues illicites / Illicit drugs
Note générale :
American Journal on Addictions, 2003, 12, (3), 253-259
Note de contenu :
fig.
Résumé :
ENGLISH :
The purpose of this study is to evaluate the effectiveness of buspirone in attenuating withdrawal symptoms in heroin addicts and methadone-maintained patients following cessation of heroin or methadone use. Subjects were twenty hospitalised male chronic opiate users aged 30-55 who did not present any DSM-IV Axis1disorder with the excep- tion of opioid dependence. For the first five days, patients received doses of methadone that were decreased to 30mg and were maintained on this dose for the following three days. Methadone was then discontinued, and patients were randomly assigned to buspirone or placebo treatment from day nine to seventeen. The buspirone dose was 15mg on day nine and 30mg from day ten to day seventeen. Treatment was double-blind. Withdrawal symptoms were measured with the Objective Opiate Withdrawal Scale (OOWS) and the Subjective Opiate Withdrawal Scale (SOWS). Buspirone-treated patients had significantly lower scores on the OOWS on days thirteen, fourteen, fifteen , and seventeen. They also had lower scores on the SOWS on days sixteen. It is concluded that buspirone was effective in attenuating the objective and subjective withdrawal symptoms that follow opiate use cessation. (Review' s abstract)
Affiliation :
VA New York Harbor HelathCare System-Brooklyn Campus (11-S/BK), 800 Poly Place, Brooklyn, NY 11209. E-mail: lbuydensworldnet.att.net
Etats-Unis. United States.
Etats-Unis. United States.