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The effectiveness of combined naloxone/lofexidine in opiate detoxification: results form a double-blind randomized and placebo-controlled trial
(L'efficacité de l'association naloxone/lofexidine dans la désintoxication des opiacés : résultats d'un essai en double aveugle, randomisé, et contre placebo.)
Auteur(s) :
BESWICK, T. ;
BEST, D. ;
BEARN, J. ;
GOSSOP, M. ;
REES, S. ;
STRANG, J.
Année
2003
Page(s) :
295-305
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
DESINTOXICATION
;
CURE DE DESINTOXICATION
;
OPIACES
;
NALOXONE
;
CLONIDINE
;
EFFICACITE
Note générale :
American Journal on Addictions, 2003, 12, (4), 295-305
Note de contenu :
fig. ; tabl.
Résumé :
ENGLISH :
The efficacy of lofexidine/naloxone was compared with lofexidine/placebo in a double-blind, randomised, placebo-controlled trial in 89 opiate-dependent patients. There were no significant differences between the two groups in the proportion of patients completing detoxification or in the length of stay. Patients in the active naloxone group demonstrated gradual reductions in levels of withdrawal and craving over the detoxification period. At completion of detoxification, patients who received naloxone maintained a level of withdrawal consistently lower than that in the placebo group; however, naloxone did not substantially accelerate the resolution of the withdrawal syndrome. Implications for future research are discussed. (Author' s abstract)
Affiliation :
Ntal Addict. Centre, 4 Windsor Walk, London SE5 8AF. E-mail: bestdpca.gov.uk
France. France.
France. France.