Historique
Article de Périodique
Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence (2003)
(Introduction d'une nouvelle approche dans le recrutement d'un échantillon pour l'étude de l'association entre facteurs génétiques et dépendance aux opioïdes)
Auteur(s) :
FRANKE, P. ;
WENDEL, B. ;
KNAPP, M. ;
SCHWAB S. G. ;
NEEF D. ;
MAIER, W. ;
WILDENAUER D. B. ;
HOEHE M. R.
Année
2003
Page(s) :
18-22
Langue(s) :
Anglais
Refs biblio. :
23
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
OPIOIDES
;
FACTEUR DE VULNERABILITE
;
GENETIQUE
;
ETUDE TRANSVERSALE
Thésaurus géographique
ALLEMAGNE
Résumé :
Objective. - In a modified case-control association study we tested the assumption that two polymorphisms (A118 in exon 1 and IVS2+31 in intron 2) of the human µ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods. - In contrast to classical case-control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results. - For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. - Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case-control association studies of opioid dependent individuals. (Author' s abstract)
Affiliation :
Dprt of Psychiatry, Univ. of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn.
Allemagne. Germany.
Allemagne. Germany.