Historique
Périodique
When "enough" is still not "enough". Effectiveness of high-dose methadone in the treatment of heroin addiction
(Quand assez n'est pas suffisant. Efficacité d'une posologie élevée en méthadone dans le traitement de l'addiction aux opiacés.)
Auteur(s) :
MAREMMANI, I. ;
PACINI, M. ;
LUBRANO S. ;
LOVRECIC, M.
Année
2003
Page(s) :
17-32
Sous-type de document :
Revue de la littérature / Literature review
Langue(s) :
Anglais
Refs biblio. :
54
Domaine :
Drogues illicites / Illicit drugs
Note générale :
Heroin Addiction and Related Clinical Problems, 2003, 5, (1), 17-32
Résumé :
ENGLISH :
In the long-standing diatribe about methadone maintenance, Dole & Nyswander were the first to support the practice of standard methadone treatment with dosages above 100 mg/day. However, several clinicians persisted in their view that lower dosages could provide most patients with significant improvement. Data from the literature strongly support the evidence that 100 mg-maintenance is more effective than that with 50 mg- in treating opiate abuse during the first 5-10 months of treatment. High dosages can be useful, bringing special benefits to patients whose opiate use has proved to be particularly resistant to treatment. Higher dosages may be used where there is a concurrent psychopathology, persistent opiate use or symptoms of incomplete coverage by methadone. Dosages above 100 mg/die, seem to give the best results. Therefore there is no scientific justification for boycotting the use of dosages between 80 and 120 mg/ day. (Author' s abstract)
Affiliation :
Dprt of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, Univ. of Pisa, Via Roma 67, 56100 Pisa
Italie. Italy.
Italie. Italy.