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Biological markers of cocaine addiction: implications for medications development
(Les marqueurs biologiques de la dépendance à la cocaïne : les implications pour le développement de médicaments.)
Auteur(s) :
ELKASHEF, A. ;
VOCCI, F.
Année
2003
Page(s) :
123-139
Sous-type de document :
Etude de synthèse / Synthetic study
Langue(s) :
Anglais
Refs biblio. :
69
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
EFFET SECONDAIRE
;
MECANISME D'ACTION
;
NEUROBIOLOGIE
;
NEUROTRANSMETTEURS
;
PHYSIOLOGIE
;
IMAGERIE MEDICALE
;
CLASSIFICATION
;
POPULATION A RISQUE
Note générale :
Addiction Biology, 2003, 8, (2), 123-139
Note de contenu :
fig. ; tabl.
Résumé :
ENGLISH :
The search for effective medications for cocaine addiction has been elusive. The failure to find such medications so far could be due to poor understanding of the underlying biology both in the premorbid condition and following the disease state of chronic cocaine use. Population heterogeneity could be a major factor in response to medications. In an attempt to highlight the issue of biomarkers we reviewed physiological, neuroendocrine and neuroimaging studies to identify specific biological changes/markers that could be used to characterize subgroups among chronic cocaine users. Merging the biology within medications studies of cocaine abusers could prove useful for targeting specific pharmacological agents to subgroups of patients, prediction of response to medication and relapse to use. (Author' s abstract)
Affiliation :
Div. Treatment, Res. Development DTR&D), NIDA, NIH, 6001 Executive Blvd, MSC 9551, Bethesda, MD, 20892-9551. E-mail: ae8a@nih.gov
Etats-Unis. United States.
Etats-Unis. United States.