Historique
Article de Périodique
Initial 3-month usage characteristics predict long-term use of benzodiazepines: an 8-year follow-up (2003)
(Les caractéristiques des trois premiers mois de consommation de benzodiazepines en prédisent l'usage à long terme : un suivi sur 8 ans)
Auteur(s) :
VAN HULTEN, R. ;
TEEUW, K. B. ;
BAKKER, A. ;
LEUFKENS, H. G.
Année
2003
Page(s) :
689-694
Langue(s) :
Anglais
Refs biblio. :
33
Domaine :
Autres substances / Other substances
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
BENZODIAZEPINES
;
CONSOMMATION
;
ABUS
;
FACTEUR DE RISQUE
;
INITIATION
;
PRESCRIPTION MEDICALE
;
ETUDE RETROSPECTIVE
Thésaurus géographique
PAYS-BAS
Note générale :
European Journal of Clinical Pharmacology, 2003, 58, (10), 689-694, tabl.
Résumé :
FRANÇAIS :
Le but de cette étude était d'identifier à partir des caractéristiques d'un usage initial de benzodiazépines, les prédicteurs d'un prolongement de la durée de l'usage. Une étude base de données de pharmacie de 8 ans (1983-1992) a été appliquée à une cohorte rétrospective de 425 nouveaux usagers. Les usages prolongés sur plusieurs années étaient associés à un nombre élevé de prescriptions initiales, de patients âgés et d'usage initial d'hypnotiques. Deux modes de prolongation irrégulière de l'usage ont été étudiés. Pendant les 90 premiers jours d'usage de bzd un nombre de déterminants d'une consommation prolongée étaient visibles. Les prescripteurs et les pharmaciens doivent avertir d'un usage rationnel non seulement lors de la première prescription mais aussi lors du premier renouvellement.
ENGLISH:
OBJECTIVE. The aim of the study was to identify initial usage predictors for prolonged benzodiazepine use. METHODS. An 8-year pharmacy data-based study (1983-1992) was carried out on a retrospective cohort of 425 initial benzodiazepine users. The setting was the only pharmacy in a community of 13,500 people. RESULTS. Among the 425 initial users, 36% had a single initial exposure year, 50% had two to seven exposure years, and 14% had benzodiazepine use during all 8 years of follow-up. Prolonged use over more years was associated with an initial high number of prescriptions, elderly patients and initial use of hypnotics. Two patterns of irregular prolonged use were investigated: increase in use was associated with a shorter length of the first usage period and switching to another benodiazepine during the first 90 days; relapses of use were associated with a shorter length of first usage period and initial use of an anxiolytic. Gender and initial dosage were not associated with prolonged use at all. CONCLUSION. During the first 90 days after initiation of benzodiazepine use, a number of determinants of prolonged benzodiazepine use were visible. The prescribers of these drugs and the pharmacists should advise rational use not only at the start but also at the moment of the first repeat prescription in order to prevent needless prolonged use and dependence.
Le but de cette étude était d'identifier à partir des caractéristiques d'un usage initial de benzodiazépines, les prédicteurs d'un prolongement de la durée de l'usage. Une étude base de données de pharmacie de 8 ans (1983-1992) a été appliquée à une cohorte rétrospective de 425 nouveaux usagers. Les usages prolongés sur plusieurs années étaient associés à un nombre élevé de prescriptions initiales, de patients âgés et d'usage initial d'hypnotiques. Deux modes de prolongation irrégulière de l'usage ont été étudiés. Pendant les 90 premiers jours d'usage de bzd un nombre de déterminants d'une consommation prolongée étaient visibles. Les prescripteurs et les pharmaciens doivent avertir d'un usage rationnel non seulement lors de la première prescription mais aussi lors du premier renouvellement.
ENGLISH:
OBJECTIVE. The aim of the study was to identify initial usage predictors for prolonged benzodiazepine use. METHODS. An 8-year pharmacy data-based study (1983-1992) was carried out on a retrospective cohort of 425 initial benzodiazepine users. The setting was the only pharmacy in a community of 13,500 people. RESULTS. Among the 425 initial users, 36% had a single initial exposure year, 50% had two to seven exposure years, and 14% had benzodiazepine use during all 8 years of follow-up. Prolonged use over more years was associated with an initial high number of prescriptions, elderly patients and initial use of hypnotics. Two patterns of irregular prolonged use were investigated: increase in use was associated with a shorter length of the first usage period and switching to another benodiazepine during the first 90 days; relapses of use were associated with a shorter length of first usage period and initial use of an anxiolytic. Gender and initial dosage were not associated with prolonged use at all. CONCLUSION. During the first 90 days after initiation of benzodiazepine use, a number of determinants of prolonged benzodiazepine use were visible. The prescribers of these drugs and the pharmacists should advise rational use not only at the start but also at the moment of the first repeat prescription in order to prevent needless prolonged use and dependence.
Affiliation :
Dept Pharmacoepidemiol. Pharmacotherapy, Utrecht Inst. Pharmaceutical Sci. (UIPS), Utrecht Univ., P.O. Box 80.082, 3508TB, Utrecht
Pays-Bas. Netherlands.
Pays-Bas. Netherlands.