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Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments
(Les perturbations majeures du sommeil dans le traitement du syndrome de sevrage des opioïdes : différences entre une désintoxication à la méthadone ou à la lofexidine.)
Auteur(s) :
BESWICK, T. ;
BEST, D. ;
REES, S. ;
BEARN, J. ;
GOSSOP, M. ;
STRANG, J.
Année
2003
Page(s) :
49-57
Langue(s) :
Anglais
Refs biblio. :
36
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
OPIOIDES
;
DESINTOXICATION
;
CURE DE DESINTOXICATION
;
TROUBLES DU SOMMEIL
;
METHADONE
;
AGONISTE
;
COMPARAISON
;
EFFICACITE
Note générale :
Addiction Biology, 2003, 8, (1), 49-57
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Sleep disturbance experienced during methadone or lofexidine opiate detoxification was investigated in 118 opiate-dependent patients receiving inpatient detoxification treatment. Sleep was assessed at four time points during opiate detoxification using a self report questionnaire. Maximum sleep disruption occurred at completion of detoxification and during the protracted withdrawal period, with patients in the methadone group reporting higher levels of withdrawal symptoms, lower overall sleep, longer sleep latencies and significantly longer periods of time awake than lofexidine patients. Regression analyses demonstrated a significant relationship between sleep disturbance, protracted withdrawal and retention in treatment, in addition to the major treatment benefit of reduced sleep disturbance conferred by lofexidine treatment. (Author' s abstract)
Affiliation :
Nat. Addiction Centre, 4 Windsor Walk, Denmark Hill, London SE5 8AF. Email : D.Best@iop.kcl.ac.uk
Royaume-Uni. United Kingdom.
Royaume-Uni. United Kingdom.