Historique
Périodique
Modulation ot the immune system in cannabis users
(Variation du système immunitaire chez les usagers de cannabis.)
Auteur(s) :
PACIFICI, R. ;
ZUCCARO, P. ;
PICHINI, S. ;
ROSET, P. N. ;
POUDEVIDA S. ;
FARRE, M. ;
SEGURA, J. ;
DE LA TORRE, R.
Année
2003
Page(s) :
1929-1931
Langue(s) :
Anglais
Refs biblio. :
6
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Journal of the American Medical Association, 2003, 289, (15), 1929-1931
Résumé :
ENGLISH :
Cannabis use was associated with a decrease in levels of IL-2, a TH1-type cytokine related to cell-mediated immunity, and an increase in levels of IL-10, a TH2-type cytokine related to humoral immunity. The decrease of proinflammatory (IL-2) cytokines and the augment of anti-inflammatory (IL-10 and TGFb1) cytokines was associated with a marked reduction in lymphocyte functionality, and a decrease in the number of NK 1 cells. The suppression of immediate and innate responses of the immune system together with the disruption of TH1/TH2 balance might increase the susceptibility and promote the progression of infectious diseases and tumors, although the clinical relevance of these findings has not been clearly demonstrated in humans. It also has been suggested that immuno-modulatory effects of cannabinoids on inflammatory and autoimmune disorders could lead to new therapeutic interventions. (Extract of the publication)
Affiliation :
Lab. Biochimica Clinica, Inst. Superiore di Sanita (ISS), Rome
Italie. Italy.
Italie. Italy.