Historique
Périodique
A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicite cocaine and opiate use in methadone-maintained patients
(Une enquête préliminaire, contrôlée, concernant l'efficacité du magnesium L-aspartate hydrochloride pour diminuer l'usage illicite de cocaine ou d'opiacés chez des patients en traitement de maintenance à la méthadone.)
Auteur(s) :
MARGOLIN, A. ;
KANTAK K. ;
COPENHAVER M. ;
AVANTS, S. K.
Année
2003
Page(s) :
49-61
Langue(s) :
Anglais
Refs biblio. :
35
Domaine :
Drogues illicites / Illicit drugs
Note générale :
Journal of Addictive Diseases, 2003, 22, (2), 49-61
Note de contenu :
tabl.
Résumé :
ENGLISH :
Based on pre-clinical studies suggesting that magnesium (Mg) reduces cocaine self-administration and potentiates the antinociceptive effects of morphine, we conducted a preliminary randomized clinical trial investigating Mg for the treatment of illicit cocaine and opiate use. Eighteen methadone-maintained patients who used illicit opiates and cocaine received either Mg (732 mg/day) or placebo for 12 weeks. Overall, findings showed that the percentage of urine screens testing positive for opiates in the Mg group (22.6%) was half that of the placebo group (46.4%), p = .04; the difference was even greater in the "medication compliant" sample (Mg: 16.3%, placebo: 47,9%), p= .02. Cocaine craving was lower in the Mg compared to the placebo group, but there was no difference between groups in cocaine use. These preliminary findings suggest that Mg may have a beneficial effect for reducing illicit opiate use. It is possible that a higher dose of Mg than was used in this study may be needed to decrease cocaine use. (Author' s abstract)
Affiliation :
Yale Univ. Sch. Med., Dept Psychiatry, Substance Abuse Ctr, 34 Park Street, New Haven, CT 06519. E-mail: arthur.margolinyale.edu
Etats-Unis. United States.
Etats-Unis. United States.