Historique
Périodique
Relationship between platelet serotonin uptake sites and treatment outcome among african-american cocaine dependent individuals
(Relation entre la capture de la sérotonine sur les sites plaquettaires et les résultats du traitement chez des individus cocaïnomanes afro-americains)
Auteur(s) :
PATKAR, A. A. ;
GOTTHEIL, E. ;
BERRETTINI, W. H. ;
THORNTON, C. C. ;
HILL, K. P. ;
WEINSTEIN, S. P.
Année
2003
Page(s) :
79-92
Langue(s) :
Anglais
Refs biblio. :
54
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Journal of Addictive Diseases, 2003, 22, (1), 79-92
Note de contenu :
tabl.
Résumé :
ENGLISH :
We investigated whether platelet tritiated paroxetine binding, a measure of serotonin uptake sites differed between cocaine-dependent subjects and controls, and whether paroxetine binding was related to treatment-outcome for cocaine patients. One hundred twenty-five African-American cocaine-dependent individuals receiving outpatient treatment and 44 controls were studied. Tritiated paroxetine binding sites on platelets were assayed and standardized assessments of behavior were performed. The outcome measures were number of negative urine drug screens, days in treatment, dropout rates and number of treatment sessions attended. Cocaine patients had significantly lower Bmax values of paroxetine binding compared to controls. Furthermore, Bmax values showed a significant positive correlation with days in treatment and negative urines. A combination of Bmax and Addiction Severity Index (ASI) employment scores improved the prediction of days in treatment and a combination of Bmax and ASI drug scores enhanced the prediction of negative urines. The findings indicate that serotonergic mechanisms may be involved in cocaine dependence and may influence treatment-outcome among cocaine patients. (Author' s abstract)
Affiliation :
Thomas Jefferson Univ., 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107. Email: ashwin.patkarmail.tju.edu
Etats-Unis. United States.
Etats-Unis. United States.