Concomitant drugs of misuse and drug using behaviours associated with fatal opiate-related poisonings in Sheffield, UK, 1997-2000

FRANÇAIS :
L'analyse rétrospective des registres du coronaire de Sheffield, de janvier 1997 à décembre 2000 montre 90 décès liés à une intoxication aux opiacés. La plupart des cas concernaient des usagers de drogues illicites par injection. Dans 20% des cas une période d'abstinence, suite à un emprisonnement ou une hospitalisation, précédait le décès et dans 60%, une polyconsommation, généralement avec de l'alcool et des benzodiazépines, était dépistée.
ENGLISH :
Aims: To examine the degree of involvement of concomitant drugs of misuse and other previously identified behavioural risk factors in acute accidental opiate-related poisoning fatalities in Sheffield, 1997-2000. Design: Retrospective analysis of coroners' records. Setting: Sheffield, UK. Participants: All those who died from an acute accidental opiate-related poisoning in Sheffield between 1 January 1997 and 11 December 2000. Measurements: Coronial data were collated under the headings: demographic characteristics, circumstances of death and toxicological findings. Findings: Ninety-four deaths occurred over the study period. The majority of cases were regular users of illicit drugs. Approximately 20% of deaths were preceded by a period of abstinence from drug use, with imprisonment and hospitalization as the most common reasons. Sixty-one per cent of cases had concomitant drugs of misuse detected from toxicology most commonly benzodiazepines and/or alcohol. These were, however, found in relatively small concentrations and opiate blood concentrations were no lower in deaths where multiple substances were involved. Despite evidence to suggest that smoking is the preferred route of heroin administration in this region, the vast majority of cases involved injecting. Conclusions: Administration of an opiate via intravenous injection was the most consistent factor associated with these deaths over the period of this study. Co-administration of other central nervous system depressants, at least in lower quantities appear to be a feature rather than a risk factor per se in such fatalities. (Author' s abstract)