Historique
Article de Périodique
The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic (2003)
(Pharmacologie clinique de la buprenorphine. Du laboratoire au traitement)
Auteur(s) :
WALSH, S. L. ;
EISSENBERG, T.
Année
2003
Page(s) :
S13-S27
Langue(s) :
Anglais
Refs biblio. :
82
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
OPIACES
;
BUPRENORPHINE
;
NALOXONE
;
PHARMACOTHERAPIE
;
DEPENDANCE PHYSIQUE
;
TOLERANCE
;
PHARMACOLOGIE
Note générale :
Drug and Alcohol Dependence, 2003, 70, (2, Suppl. 1), S13-S27
Note de contenu :
fig.
Résumé :
ENGLISH :
This paper will review clinical pharmacology studies on buprenorphine, a mixed opioid agonist-antagonist currently approved as a treatment for opioid dependence. The focus is on studies characterizing buprenorphine's pharmacodynamic actions, including its safety, abuse liability, withdrawal suppression and withdrawal precipitation capacity, physical dependence potential, cross-tolerance and duration of action as well as a review of the pharmacological profile of buprenorphine/naloxone combinations. The findings from these clinical pharmacology studies are synthesized and presented in a framework designed to (1) inform clinicians about the advantages and disadvantages of buprenorphine as an opioid maintenance agent, and (2) provide information about dosing procedures that may optimize the use of buprenorphine in the clinic. (Review's abstract.)
Affiliation :
Behavioral Pharmacology Research Unit, Dept. Psychiatr. Behav. Sci., J. Hopkins Univ., 5510 Nathan Shock Drive, Baltimore, MD 21224
Etats-Unis. United States.
Etats-Unis. United States.