Historique
Périodique
Opiate maintenance with buprenorphine in ambulatory care: a 24-week follow-up study of new users
(Traitement de maintenance ambulatoire des usagers d'opiacés par la buprénorphine : suivi à 24 semaines des nouveaux patients)
Auteur(s) :
LAPEYRE-MESTRE, M. ;
LLAU M. E. ;
GONY, M. ;
NAVEL A. M. ;
BEZ, J. ;
GRAU, M. ;
MONTASTRUC, J. L.
Année
2003
Page(s) :
297-303
Langue(s) :
Anglais
Refs biblio. :
27
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
BUPRENORPHINE
;
TRAITEMENT DE MAINTENANCE
;
SUIVI DU PATIENT
;
OBSERVANCE DU TRAITEMENT
;
RETENTION
;
COHORTE
Thésaurus géographique
FRANCE
Note générale :
Drug and Alcohol Dependence, 2003, 72, (3), 297-303
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Background: Many studies suggest that buprenorphine, a long acting partial opioid agonist, may be comparable to methadone in efficacy, with fewer withdrawal symptoms and a lower risk of overdose. The aim of this study was to assess the patterns of buprenorphine prescription use in ambulatory care and retention rate under treatment during a 24-week follow-up period. Methods: This observational cohort study included buprenorphine users identified from the French Health System prescription database in an area of 1 million inhabitants and followed for 24 weeks. Results: We selected 282 users of buprenorphine defined as "new users" (74% male, mean age 32.4 +- 6.2 years). Three groups were defined: 50% of "rational users" (141 subjects, no more than 2 prescribers), 24% of "occasional users" (67 subjects, less than 2 buprenorphine prescriptions) and 26% of "non-rational users" (74 subjects, 3 or more prescribers). The overall 24-week treatment retention rate was 37%. Misuse of buprenorphine or benzodiazepines was significantly more frequent in "non-rational" than "rational users". Conclusion: The retention rate with buprenorphine estimated in this observational study was very similar to that obtained in controlled trials. A majority of regular users of buprenorphine could be regarded as "rational users" in this area of France. (Review's abstract.)
Affiliation :
CEIP, 37 allée J. Guesde, 31073 Toulouse Cedex 7
France. France.
France. France.