Historique
Périodique
A potential hidden source of hepatitis C infection among noninjecting drug users
(Une source potentielle cachée de contamination par le virus de l'hépatite C chez les toxicomanes non injecteurs)
Auteur(s) :
MCMAHON J. M. ;
TORTU, S.
Année
2003
Page(s) :
455-460
Langue(s) :
Anglais
Refs biblio. :
54
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
HEPATITE
;
CONTAMINATION
;
VOIE NASALE
;
VOIE ORALE
;
EPIDEMIOLOGIE DESCRIPTIVE
Thésaurus géographique
ETATS-UNIS
Note générale :
Journal of Psychoactive Drugs, 2003, 35, (4), 455-460
Résumé :
ENGLISH :
Hepatitis C virus (HCV) is a major cause of chronic liver disease in the United States and worldwide. It is primarily transmitted through blood-to-blood contact with an infected individual. HCV is hyperendemic among injection drug users (IDUs), who contract the virus through contaminated syringes and drug preparation equipment shared with other IDUs. The prevalence of HCV is also high, to a lesser degree, among noninjection drug users, many of whom report no identifiable HCV risk exposures. This article reviews the epidemiological and virological evidence bearing on a potential hidden source of HCV infection among noninjection drug users: namely, the oral or intranasal transmission of HCV through the sharing of noninjection drug-use implements such as pipes or straws. While there is some epidemiological evidence supporting both oral and intranasal HCV transmission, most studies are hampered by methodological limitations. Thus, there is a need for prospective studies designed specifically to examine these potential routes of transmission. Current biological evidence does not refute either oral or intranasal transmission as possible sources of HCV infection, although more research is needed in the areas of oronasal HCV pathogenesis and the detection of HCV RNA in the nasal mucosa of intranasal drug users. (Review's abstract.)
Affiliation :
Nat. Dev. Res. Inst., 71 W. 23rd St, New York NY 10010
mcmahonndri.org
Etats-Unis. United States.
mcmahonndri.org
Etats-Unis. United States.