Auteur P. I. DARGAN

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4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4'-DMAR, 4,4'-dimethylaminorex): availability, prevalence of use, desired effects and acute toxicity

J. GLANVILLE ; P. I. DARGAN ; D. M. WOOD | 2015
Dans Human Psychopharmacology: Clinical and Experimental (Vol.30, n°3, May 2015) Article : Périodique

Objective: 4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4'-dimethylaminorex (4,4'-DMAR)) is a derivative of the controlled substances aminorex and 4-methylaminorex marketed as a potential novel psychoactive substance. This paper brin[...]

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Acute recreational drug and new psychoactive substance toxicity in Europe: 12 months data collection from the European Drug Emergencies Network (Euro-DEN)

A. M. DINES ; D. M. WOOD ; C. YATES ; F. HEYERDAHL ; K. E. HOVDA ; I. GIRAUDON ; R. SEDEFOV ; P. I. DARGAN ; Euro-DEN Research Group | 2015
Dans Clinical Toxicology (Vol.53, n°9, November 2015) Article : Périodique

CONTEXT: Despite the potential for recreational drugs and new psychoactive substances (NPSs) to cause significant morbidity and mortality, there is limited collection of systematic data on acute drug/NPS toxicity in Europe. OBJECTIVE: To report[...]

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Acute recreational drug toxicity: Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series

E. LIAKONI ; C. YATES ; A. M. DINES ; P. I. DARGAN ; F. HEYERDAHL ; K. E. HOVDA ; D. M. WOOD ; F. EYER ; M. E. LIECHTI ; Euro-DEN Plus Research Group | 2018
Dans Medicine (Vol.97, n°5, February 2018) Article : Périodique

The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity. We performed a retrospective analysis of emergency department presentations of acute recreational drug toxi[...]

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Age and sex related differences in clinical manifestations and severity of acute cocaine toxicity presentations to European emergency departments

O. MIRO ; M. GALICIA ; P. I. DARGAN ; D. M. WOOD ; A. M. DINES ; F. HEYERDAHL ; K. E. HOVDA ; M. LIECHTI ; O. M. VALLERSNES ; F. EYER ; G. BURILLO-PUTZE ; Euro-DEN Plus Research Group | 2025
Dans American Journal of Emergency Medicine (Vol.96, October 2025) Article : Périodique

The purpose of this work is to investigate if clinical manifestations and severity associated with acute cocaine toxicity differ according to patient age and sex, analyzing presentations in the Euro-DEN Plus dataset from 2013 to 2023 in which co[...]

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Analysis of anonymized pooled urine in nine UK cities: variation in classical recreational drug, novel psychoactive substance and anabolic steroid use

J. R. H. ARCHER ; S. HUDSON ; O. JACKSON ; T. YAMAMOTO ; C. LOVETT ; H. M. LEE ; S. RAO ; L. HUNTER ; P. I. DARGAN ; D. M. WOOD | 2015
Dans QJM (Vol.108, n°12, December 2015) Article : Périodique

Background: Analysis of anonymous pooled urine samples from street urinals has been used to demonstrate time-trends in the detection of classical recreational drugs and novel psychoactive substances (NPS). Aim: This study aimed to expand this t[...]

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Analysis of anonymous pooled urine from portable urinals in central London confirms the significant use of novel psychoactive substances

J. R. H. ARCHER ; P. I. DARGAN ; S. HUDSON ; D. M. WOOD | 2013
Dans QJM (Vol.106, n°2, February 2013) Article : Périodique

Aim: Analysis of urine samples collected across a city centre, for the detection of novel psychoactive substances (NPS). Design: Cross-sectional study of anonymized urine samples used for the analysis of classical recreational drugs, NPS and me[...]

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Nouveauté

Changes in clinical features and severity in patients presenting to European emergency departments with acute cannabis toxicity over the 10-year period from 2013 to 2022

O. MIRO ; M. GALICIA ; P. I. DARGAN ; D. M. WOOD ; A. M. DINES ; F. HEYERDAHL ; K. E. HOVDA ; I. GIRAUDON ; C. YATES ; M. LIECHTI ; O. M. VALLERSNES ; F. EYER ; G. BURILLO-PUTZE ; Euro-DEN Plus Research Group | 2026
Dans Addiction (Vol.121, n°2, February 2026) Article : Périodique

BACKGROUND AND AIMS: In recent years, the potency of natural cannabis products (herb and resin) has increased with a higher delta-9-tetrahydrocannabinol (Δ9-THC) content, but there are limited data on trends on clinical presentation and severity[...]

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Clinical survey assessing the appropriate management of individuals with acute recreational drug toxicity at a large outdoor festival event

J. R. H. ARCHER ; P. O. BEAUMONT ; D. MAY ; P. I. DARGAN ; D. M. WOOD | 2012
Dans Journal of Substance Use (Vol.17, n°4, August 2012) Article : Périodique

Background: The published ambulance referral criteria (ARC) for assessing individuals with acute recreational drug toxicity in the prehospital setting consist of nine domains. The ARC recommend that an ambulance is called to transfer those with [...]

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Collapse, reported seizure - and an unexpected pill

D. M. WOOD ; P. I. DARGAN ; J. BUTTON ; D. W. HOLT ; H. OVASKA ; J. RAMSEY ; A. L. JONES | 2007
Dans Lancet (The) (Vol.369, n°9571, Apr 28, 2007) Article : Périodique

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Current European data collection on emergency department presentations with acute recreational drug toxicity: gaps and national variations

F. HEYERDAHL ; K. E. HOVDA ; I. GIRAUDON ; C. B. YATES ; A. M. DINES ; R. SEDEFOV ; D. M. WOOD ; P. I. DARGAN | 2014
Dans Clinical Toxicology (Vol.52, n°10, December 2014) Article : Périodique

BACKGROUND: The number of new (novel) psychoactive substances (NPS) available in the illegal market is increasing; however, current monitoring of the drug situation in Europe focuses mainly on classical drugs of abuse, with limited emphasis on c[...]

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Do novel psychoactive substances displace established club drugs, supplement them or act as drugs of initiation? The relationship between mephedrone, ecstasy and cocaine

K. MOORE ; P. I. DARGAN ; D. M. WOOD ; F. MEASHAM | 2013
Dans European Addiction Research (Vol.19, n°5, September 2013) Article : Périodique

Background/Aims: To assess whether novel psychoactive substances (NPS) displace established club drugs, supplement them or act as drugs of initiation via a study of the relationship between mephedrone, ecstasy pills, cocaine and MDMA powder amon[...]

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Drug-related hospital emergency presentations in Europe: update from the Euro-DEN Plus expert network

OEDT = EMCDDA ; I. GIRAUDON ; A. M. DINES ; N. SINGLETON ; A. NOOR ; P. I. DARGAN ; D. WOOD | 2020
Rapport

ENGLISH: This report presents the latest findings on drug-related hospital emergencies from a network of sentinel hospitals across Europe. Almost 24 000 emergency presentations were recorded at 32 sentinel hospitals over the first 4 years of th[...]

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Document numérique

Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases

O. MIRO ; P. I. DARGAN ; D. M. WOOD ; A. M. DINES ; C. YATES ; F. HEYERDAHL ; K. E. HOVDA ; I. GIRAUDON ; Euro-DEN Plus Research Group ; M. GALICIA | 2019
Dans Clinical Toxicology (Vol.57, n°8, August 2019) Article : Périodique

Objective: To analyse the epidemiology, clinical picture and emergency department (ED) management of a large series of patients who presented to European EDs after cocaine consumption, comparing data from powder (C-1 group) and crack (C-2 group)[...]

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Ethylphenidate: availability, patterns of use, and acute effects of this novel psychoactive substance

J. H. HO ; G. P. BAILEY ; J. R. H. ARCHER ; P. I. DARGAN ; D. M. WOOD | 2015
Dans European Journal of Clinical Pharmacology (Vol.71, n°10, October 2015) Article : Périodique

Purpose: Ethylphenidate is a novel psychoactive substance that is an analogue of methylphenidate. This paper describes its availability, patterns of use, and acute effects. Methods: Searches of the scientific and grey literature (publicly acces[...]

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Evaluation of long-term detection trends of new psychoactive substances in pooled urine from city street portable urinals (London, UK)

J. R. H. ARCHER ; F. MENDES ; S. HUDSON ; K. LAYNE ; P. I. DARGAN ; D. M. WOOD | 2020
Dans British Journal of Clinical Pharmacology (Vol.86, n°3, March 2020) Article : Périodique

Aims: To evaluate the long-term trends of new psychoactive substance (NPS) detection in pooled urine samples collected across a city centre. Methods: Pooled urine samples from portable stand-alone urinals were collected on a monthly basis over[...]

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