Historique
Périodique
Relationship between platelet serotonin uptake sites and measures of impulsivity, agression, and craving among african-american cocaine abusers
(Relations entre les sites de capture de la serotonine et les mesures d'impulsivité, d'agression et de manque chez des cocaïnomanes Africano-Américains)
Auteur(s) :
PATKAR, A. A. ;
GOTTHEIL, E. ;
BERRETTINI, W. H. ;
HILL, K. P. ;
THORNTON, C. C. ;
WEINSTEIN, S. P.
Année
2003
Page(s) :
432-447
Langue(s) :
Anglais
Refs biblio. :
81
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
NEUROBIOLOGIE
;
SEROTONINE
;
NEUROTRANSMETTEURS
;
COCAINE
;
TROUBLES DU COMPORTEMENT
;
PULSION
;
VIOLENCE
;
COMPULSION
Note générale :
American Journal on Addictions, 2003, 12, (5), 432-447, tabl.
Résumé :
We investigated whether platelet-tritiated paroxetine binding, a measure of serotonin uptake sites, and behavioral measures of impulsivity, aggression, and craving differed between cocaine-dependent subjects and controls and whether paroxetine binding was related to these behavioral measures. One hundred and five African-American cocaine-dependent outpatients and 44 African-American controls were studied. Tritiated paroxetine binding sites on platelets mere assayed, and standardised assessments of impulsivity, aggression, and craving were performed. We Bmax values of paroxetine binding were significantly reduced among cocaine patients compared to controls. Cocaine patients showed significantly higher scores on certain measures of sensation seeking, impulsivity, and aggression as compared to controls. Furthermore, paroxetine binding showed a significant negative correlation with most measures of sensation seeking, impulsivity, and aggression-though not craving-among cocaine patients. Our findings indicate that densities of serotanin uptake sites may be reduced among cocaine abusers and related to impulsive-aggressive behavioral dimensions. (Author' s abstract)
Affiliation :
Thomas Jefferson Univ., 833 Chesnut Street East, Suite 210E, Philadelphia, PA 19107.
Etats-Unis. United States.
Etats-Unis. United States.