Historique
Article de Périodique
Drug seeking becomes compulsive after prolonged cocaine self-administration (2004)
(La recherche de drogues devient compulsive après une autoadministration de cocaïne prologée)
Auteur(s) :
VANDERSCHUREN L. J. M. J. ;
EVERITT, B. J.
Année
2004
Page(s) :
1017-1019
Langue(s) :
Anglais
Refs biblio. :
23
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
AUTOADMINISTRATION
;
MODELE ANIMAL
;
COMPULSION
;
BESOIN
;
THEORIE DE L'ESCALADE
Résumé :
Compulsive drug use in the face of adverse consequences is a hallmark feature of addiction, yet there is little predinical evidence demonstrating the actual progression from casual to compulsive drug use. Presentation of an aversive conditioned stimulus suppressed drug seeking in rats with limited cocaine self-administration experience, but no longer did so after an extended cocaine-taking history. In contrast, after equivalent extended sucrose experience, sucrose seeking was still suppressed by an aversive conditioned stimulus. Persistent cocaine seeking in the presence of signals of environmental adversity after a prolonged cocaine-taking history was not due to impaired fear conditioning, nor to an increase in the incentive value of cocaine, and may reflect the establishment of compulsive behavior.
Affiliation :
Rudolf Magnus Insitute of Neuroscience, Dprt of Pharmacology and Anatomy, Univ. Medical Center Utrecht, Utrecht, Netherlands