Historique
Article de Périodique
Electroencephalographic power and coherence analyses suggest altered brain function in abstinent male heroin-dependent patients (2004)
(Des analyses électroencéphalographiques suggèrent une altération de la fonction cérébrale chez des patients dépendants aux opiacés et abstinents)
Auteur(s) :
FRANKEN, I. H. A. ;
STAM, C. J. ;
HENDRIKS, V. M. ;
VAN DEN BRINK, W.
Année
2004
Page(s) :
105-110
Langue(s) :
Anglais
Refs biblio. :
43
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
IMAGERIE MEDICALE
;
CERVEAU
;
OPIACES
;
DEPENDANCE
;
COMPULSION
;
ADDICTION
;
NEUROBIOLOGIE
;
TOXICITE
Résumé :
Previous studies have shown that drug abuse is associated with altered brain function. However, studies of heroin abuse-related brain dysfunctions are scarce. Electroencephalographic (EEG) power and coherence analyses are two important tools for examining the effects of drugs on brain function. In the present study, we compared EEG power and coherence measures of 18 abstinent heroin-dependent subjects with those of 12 healthy control subjects. Furthermore, within the heroin group, associations between heroin use in the past, heroin craving and these EEG measures were studied. The results show that heroin-dependent subjects have increased relative beta-2 power and increased left intrahemispheric gamma coherence compared with control subjects. Furthermore, coherence measures showed correlations with clinical variables. These EEG abnormalities may reflect underlying changes in brain function due to longterm drug abuse and premorbid characteristics. (Author's abstract.)
Affiliation :
Pays-Bas. Netherlands.