Historique
Périodique
Neurological and cognitive impairment associated with leaded gasoline encephalopathy
(Troubles neurologiques et cognitifs associés à une encéphalopathie au plomb contenu dans l'essence)
Auteur(s) :
CAIRNEY, S. ;
MARUFF P. ;
BURNS, C. B. ;
CURRIE, J. ;
CURRIE, J. B.
Année
2004
Page(s) :
183-188
Langue(s) :
Anglais
Refs biblio. :
35
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
INHALANTS
;
TOXICITE
;
SNIFFER
;
INTOXICATION
;
SYSTEME NERVEUX CENTRAL
;
PATHOLOGIE ORGANIQUE
Note générale :
Drug and Alcohol Dependence, 2004, 73, (2), 183-188
Résumé :
Background: A toxic encephalopathy (or 'lead encephalopathy') may arise from leaded gasoline abuse that is characterised by tremor, hallucinations, nystagmus, ataxia, seizures and death. This syndrome requires emergency and intensive hospital treatment. Methods: We compared neurological and cognitive function between chronic gasoline abusers with (n = 15) and without (n = 15) a history of leaded gasoline encephalopathy, and with controls who had never abused gasoline (n = 15). Results: Both groups of chronic gasoline abusers had abused gasoline for the same length of time and compared to controls, showed equivalently elevated blood lead levels and cognitive abnormalities in the areas of visuo-spatial attention, recognition memory and paired associate learning. However, where gasoline abusers with no history of leaded gasoline encephalopathy showed only mild movement abnormalities, gasoline abusers with a history of leaded gasoline encephalopathy showed severe neurological impairment that manifest as higher rates of gait ataxia, abnormal rapid finger tapping, finger to nose movements, dysdiadochokinesia and heel to knee movements, increased deep tendon reflexes and presence of a palmomental reflex. Conclusions: While neurological and cognitive functions are disrupted by chronic gasoline abuse, leaded gasoline encephalopathy is associated with additional and long-lasting damage to cortical and cerebellar functions.
Affiliation :
Cogstate Ltd., 51 Leicester St., Carlton, Victoria 3053
Australie. Australia.
Australie. Australia.