Historique
Périodique
Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence
(Méthadone ou morphine à libération retardée par voie orale : une comparaison croisée des résultats obtenus chez les patients et de l'acceptabilité en tant que pharmacothérapie de maintenance pour la dépendance aux opiacés)
Auteur(s) :
MITCHELL, T. B. ;
WHITE, J. M. ;
SOMOGYI A. A. ;
BOCHNER F.
Année
2004
Page(s) :
940-945
Langue(s) :
Anglais
Refs biblio. :
22
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
ACCEPTABILITE
;
METHADONE
;
MORPHINE
;
VOIE ORALE
;
COMPARAISON
;
TRAITEMENT DE MAINTENANCE
;
PRODUIT DE SUBSTITUTION
;
OPIACES
;
ETUDE TRANSVERSALE
Note générale :
Addiction, 2004, 99, (8), 940-945
Résumé :
ENGLISH :
Aims To evaluate slow-release oral morphine (SROM) as an alternative maintenance pharmacotherapy to methadone for treatment of opioid dependence. Design Open-label crossover study Setting Out-patient methadone maintenance programme. Participants Eighteen methadone maintenance patients. Intervention Participants were transferred from methadone to SROM (once-daily Kapanol tm) for approximately 6 weeks before resuming methadone maintenance. Measurements Patient outcomes were assessed (1) during the transition between medications (dose requirements, withdrawal severity) and (2) after at least 4 weeks on a stable dose of each drug (treatment preference. patient ratings of treatment efficacy and acceptability. drug use, health, depression and sleep). Findings Transfer from methadone to SROM was associated with relatively mild withdrawal for the first 5 days: the final mean SROM : methadone dose ratio was 4.6 : 1. Compared to methadone, SROM was associated with improved social functioning, weight loss. Fewer and less troublesome side-effects, greater drug lilting, reduced heroin craving, an enhanced sense of feeling 'normal' and similar outcomes for unsanctioned drug use, depression and health. The majority of subjects preferred SROM (78%) over methadone (22%). Conclusions These findings provide justification for further evaluation of SROM as a maintenance pharmacotherapy for opioid dependence. (Author' s abstract)
Affiliation :
National Addiction Centre Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF. Email : t.mitchelliop.kcl.ac.uk
Royaume-Uni. United Kingdom.
Royaume-Uni. United Kingdom.