Historique
Périodique
Cannabis use and the risk of later schizophrenia : a review
(Usage de cannabis et risque de schizophrénie consécutive. Etude de synthèse)
Auteur(s) :
SMIT, P. ;
BOLIER, L. ;
CUIJPERS, P.
Année
2004
Page(s) :
425-430
Sous-type de document :
Etude de synthèse / Synthetic study
Langue(s) :
Anglais
Refs biblio. :
22
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
CANNABIS
;
TROUBLE BIPOLAIRE
;
SCHIZOPHRENIE
;
PSYCHOSE
;
AUTOMEDICATION
;
EFFET SECONDAIRE
;
FACTEUR DE VULNERABILITE
;
POPULATION A RISQUE
;
ETIOLOGIE
Note générale :
Addiction, 2004, 99, (4), 425-430
Note de contenu :
tabl.
Résumé :
FRANÇAIS :
Examen de 5 études longitudinales ayant étudié la relation entre usage de cannabis et expérience consécutive de symptômes psychotiques ayant nécessité une hospitalisation lors de laquelle le diagnostic de schizophrénie a pu être confirmé.
ENGLISH :
Aim : To study the role of cannabis use in the onset of symptoms and disorders in the schizophrenia spectrum. Design : Review of five population-based, longitudinal studies on the relationship between cannabis use and problems ranging from the experience of psychotic symptoms to hospitalization with a confirmed diagnosis of schizophrenia. Several hypotheses are examined that may explain this relationship : (1) self medication ; (2) effects of other drugs ; (3) confounding ; (4) stronger effect in predisposed people, and (5) etiological hypothesis. Findings : Hypotheses 1 and 2 can be dismissed ; hypothesis 3 is still open to debate, and converging evidence is found for hypotheses 4 and 5 - antecedent cannabis use appears to act as a risk factor in the onset of schizophrenia, especially in vulnerable people, but also in people without prior history. Conclusion : There is an intrinsic message here for public health, but how that message is to be translated into action is not immediately clear. (Review' s abstract)
Examen de 5 études longitudinales ayant étudié la relation entre usage de cannabis et expérience consécutive de symptômes psychotiques ayant nécessité une hospitalisation lors de laquelle le diagnostic de schizophrénie a pu être confirmé.
ENGLISH :
Aim : To study the role of cannabis use in the onset of symptoms and disorders in the schizophrenia spectrum. Design : Review of five population-based, longitudinal studies on the relationship between cannabis use and problems ranging from the experience of psychotic symptoms to hospitalization with a confirmed diagnosis of schizophrenia. Several hypotheses are examined that may explain this relationship : (1) self medication ; (2) effects of other drugs ; (3) confounding ; (4) stronger effect in predisposed people, and (5) etiological hypothesis. Findings : Hypotheses 1 and 2 can be dismissed ; hypothesis 3 is still open to debate, and converging evidence is found for hypotheses 4 and 5 - antecedent cannabis use appears to act as a risk factor in the onset of schizophrenia, especially in vulnerable people, but also in people without prior history. Conclusion : There is an intrinsic message here for public health, but how that message is to be translated into action is not immediately clear. (Review' s abstract)
Affiliation :
Trimbos Inst., PO Box 725, 3500 AS Utrecht ; fsmittrimbo.nl
Norvège. Norway.
Norvège. Norway.