Historique
Périodique
Effects of 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) on the self-administration of cocaine, heroin, and cocaine/heroin combinations in rats
(Action du 2béta-propanoyl-3béta-(4-tolyl)-tropane (PTT) sur l'autoadministration de cocaine, d'héroïne ou des deux drogues chez le rat)
Auteur(s) :
SIZEMORE G. M. ;
DAVIES, H. M. L. ;
MARTIN, T. J. ;
SMITH, J. E.
Année
2004
Page(s) :
259-265
Langue(s) :
Anglais
Refs biblio. :
39
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 2004, 73, (3), 259-265
Note de contenu :
fig.
Résumé :
ENGLISH :
Pharmacotherapies utilizing long-acting agonists and mixed function agonists-antagonists have been successful in the treatment of opiate addiction but no comparable treatment exists for cocaine abuse. Long-acting tropane analogues have been synthesized that could be candidates for such pharmacotherapies. 2beta-Propanoyl-3beta-(4-tolyl)-tropane (PTT) is one such compound that is a relatively selective dopamine (DA) transporter blocker that has a significantly longer duration of action than cocaine. The purpose of this study was to assess the effects of PTT on the intravenous self-administration of cocaine, heroin, or cocaine/heroin combinations. Groups of rats were trained to self-administer cocaine, heroin, or cocaine/heroin combinations using a within session dosing procedure in which three doses were available each session. PTT pretreatment reduced cocaine and cocaine/heroin combinations intake in a dose-dependent manner while having only minor effects on heroin intake. These results suggest that the neurobiological substrates of cocaine and heroin self-administration are different, and that these cocaine/heroin combinations may function more like cocaine alone, even when the dose of heroin in the mixture will function independently as a reinforcer. These results further support the potential use of long-acting dopamine reuptake inhibitors as pharmacotherapeutic adjuncts to a comprehensive treatment program for cocaine and cocaine/heroin abuse. (Review's abstract.)
Affiliation :
Dept. Physiol. Pharmacol., Wake Forest Univ. Hlth Sci., Med. Ctr. Bld. Winston-Salem, NC 27157-1083
Etats-Unis. United States.
Etats-Unis. United States.