Historique
Périodique
A randomized, placebo-controlled trial of buspirone for the treatment of anxiety in opioid-dependant individuals
(Un essai randomisé, contre placebo, sur l'efficacité de la buspirone dans le traitement de l'anxiété chez des usagers dépendants des opioïdes.)
Auteur(s) :
MCRAE, A. L. ;
SONNE, S. C. ;
BRADY, K. T. ;
DURKALSKI V. ;
PALESCH Y.
Année
2004
Page(s) :
53-63
Langue(s) :
Anglais
Refs biblio. :
29
Domaine :
Drogues illicites / Illicit drugs
Note générale :
American Journal on Addictions, 2004, 13, (1), 53-63
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Anxiety symptoms are common among opioid dependent individuals. Buspirone, a non benzodiazepine anxiolytic, has been used successfully for the treatment of anxiety in alcoholic patients. Its efficacy in opioid-dependent patients has not been previously examined. We conducted a twelve-week, randomized, placebo-controlled trial of buspirone in 36 subjects receiving methadone-maintenance treatment who presented with anxiety symptoms. Measures of anxiety, depression, and substance use were obtained repeatedly during treatment. Buspirone treatment did not significantly reduce anxiety symptoms in opioid-dependent patients. However, buspirone treatment was associated with trends toward reduction in depression scale scores and a slower return to substance use. (Review' s abstract)
Affiliation :
Dr Mc Rae, Clinical Res. Neuroscience Div., 61 President St., Charleston, SC 29425 ; mcraealmusc.edu.
Etats-Unis. United States.
Etats-Unis. United States.