Historique
Périodique
Choosing a behavioral therapy platform for pharmacotherapy of substance users
(Choisir un pannel de thérapies comportementales pour renforcer le traitement pharmacologique des usagers de drogue)
Auteur(s) :
CARROLL, K. M. ;
KOSTEN, T. R. ;
ROUNSAVILLE, B. J.
Année
2004
Page(s) :
123-134
Langue(s) :
Anglais
Refs biblio. :
114
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
PSYCHOTROPES
;
DEPENDANCE
;
PHARMACOTHERAPIE
;
THERAPIE COMPORTEMENTALE
;
OBSERVANCE DU TRAITEMENT
Note générale :
Drug and Alcohol Dependence, 2004, 75, (2), 123-134
Note de contenu :
tabl.
Résumé :
ENGLISH :
Behavioral therapy platforms have become virtual requirements in pharmacotherapy trials due to their utility in reducing noise variability, preventing differential medication adherence and protocol attrition, enhancing statistical power and addressing ethical issues in placebo-controlled trials. Selecting an appropriate behavioral platform for a particular trial requires study-specific tailoring, taking into account both the stage of development of the medication being evaluated, as well as the specific strengths and weaknesses of a broad array of available empirically supported behavioral therapies and the range of their possible targets (e.g., enhancing medication adherence, preventing attrition, addressing co-morbid problems, fostering abstinence, and targeting specific weaknesses of the pharmacologic agent). Choosing a suitable behavioral plat- form also requires consideration of the characteristics of the population to be treated, stage of scientific knowledge regarding the medication's effects, appropriate balance of internal and external validity, and consideration of potential ceiling effects. Available manualized behavioral treatments are reviewed, noting their strengths and limitations as behavioral therapy platforms for pharmacotherapy trials and as potential concomitant therapies in clinical practice. (Review's abstract.)
Affiliation :
Dept. Psychiatr., Yale Univ. Sch. Med., VA CT Healthcare Ctr., 950 Campbell Ave., West Haven, CT 06516
Etats-Unis. United States.
Etats-Unis. United States.