Historique
Périodique
Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users
(Effets à long terme de la kétamine : persistance des troubles de la mémoire chez les usagers récréatifs)
Auteur(s) :
MORGAN, C. J. A. ;
RICCELLI M. ;
MAITLAND, C. H. ;
CURRAN, H. V.
Année
2004
Page(s) :
301-308
Langue(s) :
Anglais
Refs biblio. :
43
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
KETAMINE
;
MEMOIRE
;
MESUSAGE
;
USAGE RECREATIF
;
ABUS
;
TROUBLES DE LA MEMOIRE
;
COGNITION
Note générale :
Drug and Alcohol Dependence, 2004, 75, (3), 301-308
Résumé :
Rationale: Ketamine is an N-methyl-D-aspartate (NMDA)-receptor antagonist that is increasingly being used as a recreational drug. Previous research has shown gross generalised verbal memory impairments persisting 3 days after ketamine use in chronic users, however episodic memory has not specifically investigated in this population. Objective: To determine whether ketamine, on the night of drug use (day 0) and 3 days later, is associated with impaired episodic memory as assessed by a source memory task. Methods: Twenty ketamine users and 20 poly-drug controls were compared on a source memory task both on day 0 and 3. Participants also completed questionnaires on both days indexing schizophrenic-like and dissociative symptoms. Results: On day 0, ketamine abusers were impaired on both source memory and item recognition and scored more highly on schizophrenic and dissociative symptom scales compared to poly-drug controls. On day 3 ketamine abusers only displayed source memory impairments and these positively correlated with the level of schizophrenic-like symptoms on day 0. No differences on day 3 in schizophrenic-like or dissociative symptoms were observed. Conclusions: Ketamine abusers exhibit a persisting deficit in source memory on day 3 but not in item recognition. These findings suggest that repeated use of ketamine produces chronic impairments to episodic memory. (Review's abstract.)
Affiliation :
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, Gower St., London WC1E 6BT, UK