Historique
Périodique
Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach
(Usage et abus/dépendance de drogues illicites : une comparaison des variables influençant ces deux étapes de la consommation à partir de l'approche CCC, qui différentie les facteurs Causals, Communs et Contingents)
Auteur(s) :
AGRAWAL, A. ;
NEALE, M. C. ;
JACOBSON, K. C. ;
PRESCOTT, C. A. ;
KENDLER, K. S.
Année
2005
Page(s) :
1043-1048
Langue(s) :
Anglais
Refs biblio. :
12
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
EPIDEMIOLOGIE
;
CONSOMMATION
;
ABUS
;
DEPENDANCE
;
TYPE D'USAGE
;
COMPARAISON
;
ETIOLOGIE
;
EVALUATION
;
GENETIQUE
;
MODELE
;
SEXE
Note générale :
Addictive Behaviors, 2005, 30, (5), 1043-1048
Note de contenu :
tabl.
Résumé :
ENGLISH :
Drug use and abuse/dependence are stages of a complex drug habit. Most genetically informative: models that are tit to twin data examine drug use and abuse/dependence independent of each other. This poses an interesting question: for a multistage process, how can we partition the factors influencing each stage specifically from the factors that are common to both stages? We used a causal-common-contingent (CCC) model to partition the common and specific influences on drug use and abuse/dependence. Data on use and abuse/dependence of cannabis, cocaine, sedatives. stimulants and any illicit drug was obtained from male and female twin pairs. CCC models were tested individually for each sex and in a sex-equal model. Our results suggest that there is evidence for additive genetic, shared environmental and unique environmental influences that are common to illicit drug use and abuse/dependence. Furthermore, we found substantial evidence for factors that were specific to abuse/dependence. Finally, sexes could be equated for all illicit drugs. The findings of this study emphasize the need for models that can partition the sources of individual differences into common and stage-specific influences. (Editor's abstract.)
Affiliation :
Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Box 980003 Suite 1-154, Richmond, VA 23298-0003. E-mail : arpana_vipbgyahoo.com
Etats-Unis. United States.
Etats-Unis. United States.