Historique
Périodique
Short-term outcomes of five heroin detoxification methods in the Australian NEPOD Project
(Comparaison des résultats à court terme de cinq méthodes de désintoxication de l'héroïne : une étude menée dans le cadre du Projet Australien NEPOD (Evaluation Nationale des Pharmacothérapies de la Dépendance aux Opiacés)
Auteur(s) :
DIGIUSTO, E. ;
LINTZERIS, N. ;
BREEN, C. ;
KIMBER, J. ;
MATTICK, R. P. ;
BELL, J. ;
ALI, R. ;
SAUNDERS, J. B.
Année
2005
Page(s) :
443-456
Langue(s) :
Anglais
Refs biblio. :
27
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
DESINTOXICATION
;
EVALUATION
;
PHARMACOTHERAPIE
;
OPIACES
;
HEROINE
;
CURE DE DESINTOXICATION
;
COMPARAISON
;
EFFICACITE
Thésaurus géographique
AUSTRALIE
Note générale :
Addictive Behaviors, 2005, 30, (3), 443-456
Note de contenu :
tabl.
Résumé :
ENGLISH :
This study included 380 participants in five heroin detoxification trials whose data were pooled to enable direct comparison of five detoxification methods in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD). Rapid detoxification achieved similar initial abstinence rates with either anaesthesia or sedation (average 59%), which were higher than was achieved by inpatient detoxification using clonidine plus other symptomatic medications (24%), which in turn was higher than outpatient detoxification using either buprenorphine (12%) or elonidine plus other symptomatic medications (4%). Older participants and those using more illicit drugs were more likely to achieve abstinence. Entry rates into ongoing postdetoxification treatment were as follows: buprenorphine outpatient (65%), sedation (63%), anaesthesia (42%), symptomatic outpatient (27%), and symptomatic inpatient (12%). Postdetoxification treatment with buprenorphine or methadone was preferred over naltrexone. Participants with more previous detoxification attempts were more likely to enter postdetoxification treatment. Given that outpatient detoxification was more effective with buprenorphine than with symptomatic medications and that rapid detoxification was more effective than the symptomatic inpatient method, the roles of the symptomatic methods should be reconsidered. (Editor's abstract.)
Affiliation :
National Centre in HIV Social Research, University of New South Wales, Sydney NSW 2052. E-mail : e.digiustounsw.edu.au
Australie. Australia.
Australie. Australia.