Historique
Périodique
Cannabis use predicts future psychotic symptoms, and vice versa
Auteur(s) :
FERDINAND, R. F. ;
SONDEIJKER, F. ;
VAN DER ENDE, J. ;
SELTEN, J. P. ;
HUIZINK, A. C. ;
VERHULST, F. C.
Année
2005
Page(s) :
612-618
Langue(s) :
Anglais
Refs biblio. :
37
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
CANNABIS
;
TROUBLE BIPOLAIRE
;
ADOLESCENT
;
PSYCHOSE
;
SYMPTOME
;
FACTEUR DE RISQUE
Thésaurus géographique
PAYS-BAS
Note générale :
Addiction, 2005, 100, (5), 612-618
Résumé :
AIMS: To assess if cannabis use is a risk factor for future psychotic symptoms, and vice versa, in adolescents and young adults from the general population.
DESIGN: Cohort study.
SETTING/PARTICIPANTS: 'Zuid Holland' study, a 14-year follow-up study of 1580 initially 4-16-year-olds who were drawn randomly from the Dutch general population. Because cannabis use is generally condoned in the Netherlands, false-negative reports of cannabis use may occur less frequently than in countries with stricter drug policies, which supports the value of the present study.
MEASUREMENTS: Life-time cannabis use and psychotic symptoms, assessed with the Composite International Diagnostic Interview (CIDI).
FINDINGS: Cannabis use, in individuals who did not have psychotic symptoms before they began using cannabis, predicted future psychotic symptoms (hazard ratio = 2.81; 95% confidence interval = 1.79-4.43). However, psychotic symptoms in those who had never used cannabis before the onset of psychotic symptoms also predicted future cannabis use (hazard ratio = 1.70; 95% confidence interval = 1.13-2.57).
CONCLUSIONS: The results imply either a common vulnerability with varying order of onset or a bi-directional causal relationship between cannabis use and psychosis. More research on patterns and timings of these relationships is needed to narrow down the possibilities.
DESIGN: Cohort study.
SETTING/PARTICIPANTS: 'Zuid Holland' study, a 14-year follow-up study of 1580 initially 4-16-year-olds who were drawn randomly from the Dutch general population. Because cannabis use is generally condoned in the Netherlands, false-negative reports of cannabis use may occur less frequently than in countries with stricter drug policies, which supports the value of the present study.
MEASUREMENTS: Life-time cannabis use and psychotic symptoms, assessed with the Composite International Diagnostic Interview (CIDI).
FINDINGS: Cannabis use, in individuals who did not have psychotic symptoms before they began using cannabis, predicted future psychotic symptoms (hazard ratio = 2.81; 95% confidence interval = 1.79-4.43). However, psychotic symptoms in those who had never used cannabis before the onset of psychotic symptoms also predicted future cannabis use (hazard ratio = 1.70; 95% confidence interval = 1.13-2.57).
CONCLUSIONS: The results imply either a common vulnerability with varying order of onset or a bi-directional causal relationship between cannabis use and psychosis. More research on patterns and timings of these relationships is needed to narrow down the possibilities.
Affiliation :
Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam/Sophia Children's Hospital, Rotterdam, Netherlands