Historique
Périodique
Use of slow-release oral morphine for the treatment of opioid dependence
(Utilisation de la morphine retard par voie orale dans le traitement de la dépendance aux opiacés)
Auteur(s) :
KRAIGHER, D. ;
JAGSCH, R. ;
GOMBAS W. ;
ORTNER, R. ;
EDER, H. ;
PRIMORAC, A. ;
FISCHER, G.
Année
2005
Page(s) :
145-151
Langue(s) :
Anglais
Refs biblio. :
50
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
MORPHINE
;
DISTRIBUTION CONTROLEE
;
TRAITEMENT DE MAINTENANCE
;
VOIE ORALE
;
EFFICACITE
;
OPIOIDES
Thésaurus géographique
AUTRICHE
Note générale :
European Addiction Research, 2005, 11, (3), 145-151
Résumé :
Aims: In addition to methadone, other synthetic opioids are now available for the treatment of opioid dependence. The study investigated the treatment satisfaction of oral slow-release morphine for maintenance therapy in opioid-dependent patients in an open-label 3-week study. Design: We evaluated the treatment satisfaction of oral slow-release morphine hydrochloride for 3 weeks in 110 patients meeting the diagnosis of opioid dependence (DSM-IV 304.0) or polysubstance dependence (DSM-IV 304.9). Measurements: Primary outcome measures were the study retention rate, urinalysis for additional illicit consumption other than heroin, cravings and withdrawal symptoms 24 h after the last intake of the medication (duration of action of treatment). Findings: In total, 103 patients completed the study, representing a retention rate of 94%. Patients reported significant improvements in somatic complaints, as well as significant reductions in heroin and cocaine cravings (p < 0.0001) and in additional consumption of cocaine in supervised urinalysis (p = 0.0083). Additional illicit consumption of benzodiazepines remained unchanged. Conclusions: The high study retention rate implies a good acceptance of slow-release acting oral morphine. However, randomised, double-blind, double-dummy studies with a longer investigational period are needed to meet criteria for evidence-based medicine. (Author's abstract.)
Affiliation :
Addiction Clinic, Department of General Psychiatry, University Hospital of Vienna, Vienna, Austria
Cote :
Abonnement