Historique
Périodique
Lack of hippocampal volume change in long-term heavy cannabis users
(Le volume de l'hippocampe ne change pas chez les usagers à long terme de cannabis.)
Auteur(s) :
TZILOS, G. K. ;
CINTRON C. B. ;
WOOD, J. B. R. ;
SIMPSON, N. S. ;
YOUNG, A. D. ;
POPE, H. G. ;
YURGELUN-TODD D. A.
Année
2005
Page(s) :
64-72
Langue(s) :
Anglais
Refs biblio. :
33
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
American Journal on Addictions, 2005, 14, (1), 64-72
Note de contenu :
tabl.
Résumé :
ENGLISH :
The effects of cannabis smoking on the morphology of the hippocampus are still unclear, especially because previous human studies have examined primarily younger, shorter-term users. We used magnetic resonance imaging to investigate these effects in a group of 22 older, long-term cannabis users (reporting a mean [SD] of 20,100 [13,900] lifetime episodes of smoking) and 26 comparison subjects with no history of cannabis abuse or dependence. When compared to control subjects, smokers displayed no significant adjusted differences in volumes of gray matter, white matter, cerebrospinal fluid, or left and right hippocampus. Moreover, hippocampal volume in cannabis users was not associated with age of onset of use nor total lifetime episodes of use. These findings are consistent with recent literature suggesting that cannabis use is not associated with structural changes within the brain as a whole or the hippocampus in particular. (Review' s abstract)
Affiliation :
Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hosp., Harvard Med. School, 115 Mill St., Belmont, MA 02478. E Mail : ytoddmclean.harvard.edu
Etats-Unis. United States.
Etats-Unis. United States.