Historique
Périodique
Co-consumption of benzodiazepines in heroin users, methadone-substitute patients
(Polyconsommation de benzodiazépines et d'héroïne chez des patients substitués à la méthadone.)
Auteur(s) :
BACKMUND, M. ;
MEYER, K. ;
HENKEL, C. ;
SOYKA, M. ;
REIMER, J. ;
SCHÜTZ, C. G.
Année
2005
Page(s) :
17-29
Langue(s) :
Anglais
Refs biblio. :
31
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus géographique
ALLEMAGNE
Thésaurus mots-clés
BENZODIAZEPINES
;
HEROINE
;
TRAITEMENT DE MAINTENANCE
;
POLYCONSOMMATION
;
EPIDEMIOLOGIE DESCRIPTIVE
;
ETUDE RETROSPECTIVE
Note générale :
Journal of Addictive Diseases, 2005, 24, (4), 17-29
Note de contenu :
tabl.
Résumé :
ENGLISH :
Concomitant consumption of benzodiazepines (BZDs) and opioids is a major problem in patients with opioid dependence. It may have substantial impact on morbidity, mortality and clinical course. The current retrospective study aims to determine whether there are differences in the additional use of BZDs among addicts regularly taking methadone or codeine medications in treatment and untreated addicts injecting heroin. The records of 1,685 patients admitted for detoxification were analyzed using bivariate analysis and multiple logistic regression analysis. Demographic and drug related variables were considered, both as possible confounders and predictors of concomitant BZD use. Daily intake of BZDs was reported in 44.4% of the patients. Patients treated with methadone or codeine medications report daily intake of BZDs significantly more often than the heroin-dependent patients (p < 0.01).Using multiple regression analyses, the results were confirmed as independent from the assessed possible confounders. Further we found that daily use of alcohol or barbiturates, early onset of opioid use (p < 0.01), unemployment, having a substance dependent family member with, and a history of imprisonment (for all p < 0.05) were associated with concomitant daily consumption of BZDs in opioid dependent subjects. These finding underline the need to further explore the causes, interactions and consequences of concomitant BZD and opiate use. (Author' s abstract)
Affiliation :
Dept of Addiction Medicine, Internal Clinic 3, General Hospital Schwabing Munich, Kölner Platz 1, 80804 München. E-mail: Markus.Backmunekms.mhn.de
Allemagne. Germany.
Allemagne. Germany.