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The effect of alcohol on the neuropsychological functioning of recently abstinent cocaine-dependent subjects
(L'effet de l'alcool sur les fonctions neuropsychologiques d'usagers de cocaïne récemment abstinents.)
Auteur(s) :
ABI-SAAB, D. ;
BEAUVAIS, J. ;
MEHM, J. ;
BRODY, M. ;
GOTTSCHALK, C. ;
KOSTEN, T. R.
Année
2005
Page(s) :
166-178
Langue(s) :
Anglais
Refs biblio. :
42
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
ALCOOL
;
COCAINE
;
EFFET SECONDAIRE
;
TROUBLES DE LA MEMOIRE
;
TROUBLES DE LA PERCEPTION
;
APPRENTISSAGE
;
INTERACTION CHIMIQUE
Note générale :
American Journal on Addictions, 2005, 14, (2), 166-178
Résumé :
Neuropsychological deficits in the areas of learning, memory, attention, and abstraction abilities have been associated with cocaine dependence, especially during the period of early abstinence. Although cocaine users tend to be multidrug users, few studies have focused on the combined effect of alcohol and cocaine on neuropsychological functioning. Consistent with prior research, results from the current study indicated that cocaine-dependent subjects showed a significantly greater degree of neuropsychological impairment as compared to controls. In addition, cocaine-dependent subjects with a history of alcohol disorder showed less memory impairment but similar impairments in attention and overall neuropsychological functioning as cocaine subjects with no such history. The vasodilatation produced by alcohol may attenuate some of the vasoconstriction and neurotoxic effects of cocaine, accounting for the fewer deficits in this group. (Author' s abstract)
Affiliation :
Yale University School of Medicine, VA Connecticut Healthcare System, West Haven Campus, Department of Psychiatry, 116A, 950 Campbell Ave, West Haven, CT 06516.
Etats-Unis. United States.
Etats-Unis. United States.