Historique
Périodique
Acute phase and five-year follow-up study of fluoxetine in adolescents with major depresssion and a comorbid substance use disorder: a review
(Usage de fluoxétine en phase de crise et étude de suivi sur 5 ans chez des adolescents souffrant d'une grave dépression et d'une comorbidité de troubles liés à l'usage de substances psychoactives : une revue)
Auteur(s) :
CORNELIUS, J. R. ;
CLARK, D. B. ;
BUKSTEIN, O. G. ;
BIRMAHER, B. ;
SALLOUM I. M. ;
BROWN, S. A.
Année
2005
Page(s) :
1824-1833
Langue(s) :
Anglais
Refs biblio. :
29
Domaine :
Plusieurs produits / Several products
Thésaurus mots-clés
COMORBIDITE
;
DEPRESSION
;
ADOLESCENT
;
ANTIDEPRESSEURS
;
SUIVI DU PATIENT
;
ETUDE LONGITUDINALE
Note générale :
Addictive Behaviors, 2005, 30, (9), 1824-1833
Résumé :
ENGLISH :
This paper reviews the results of an acute phase trial and a five-year follow-up study fluoxetine in adolescent with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents. followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor. (Editor's abstract.)
Affiliation :
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, PAARC Suite, Pittsburgh, PA 15213. E-mail : jcornelpitt.edu
Etats-Unis. United States.
Etats-Unis. United States.