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Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects
(Effets aigus de la cocaïne sur deux modèles de contrôle de linhibition : implications deffets-dose non linéaires.)
Auteur(s) :
FILLMORE, M. T. ;
RUSH, C. R. ;
HAYS, L.
Année
2006
Page(s) :
1323-1332
Langue(s) :
Anglais
Refs biblio. :
14
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
EFFET SECONDAIRE
;
INHIBITION
;
TROUBLES DU COMPORTEMENT
;
TROUBLES DE LA MEMOIRE
;
TEST
Note générale :
Addiction, 2006, 101, (9), 1323-1332
Résumé :
Aims: This study examined doseresponse effects of oral cocaine on the inhibitory control of behavior in adult cocaine users using two different behavioral models of inhibitory control. Design: Adults (n = 12) with a history of cocaine use performed the stop-signal and cue-dependent gono-go task to measure inhibitory control of behavior in response to a range of oral cocaine HCl doses (0, 100, 200 and 300 mg). Findings: Although both tasks showed cocaine-induced facilitation of inhibitory control, doseresponse functions differed depending on the measures. The stop-signal measure revealed a quadratic doseresponse function and the cued gono-go measure showed a more orderly, linear improvement as a function of dose. Conclusions: The evidence suggests a two-phasic doseresponse in which facilitating effects of stimulant drugs on inhibitory control might be limited to a range of intermediate doses, above which improvement is no longer evident and impairing effects could possibly emerge. (Author' s abstract)
Affiliation :
Department of Psychology, University of Kentucky, Lexington, KY. 405060044.
Etats-Unis. United States.
Etats-Unis. United States.