Historique
Périodique
Systemic disease among cases of fatal opioid toxicity
(Troubles systémiques parmi des cas de toxicité fatale liée aux opioïdes.)
Auteur(s) :
DARKE, S. ;
KAYE, S. ;
DUFLOU, J.
Année
2006
Page(s) :
1299-1305
Langue(s) :
Anglais
Refs biblio. :
33
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
OPIOIDES
;
TOXICITE
;
SURDOSE
;
AUTOPSIE
;
PATHOLOGIE ORGANIQUE
;
APPAREIL RESPIRATOIRE
;
APPAREIL CARDIOVASCULAIRE
;
REIN
;
FOIE
Note générale :
Addiction, 2006, 101, (9), 1299-1305, tabl.
Résumé :
Aims: To determine levels of systemic disease among cases of death due to opioid toxicity. Design: Analysis of coronial cases. Setting: Sydney, Australia. Cases: A total of 841 cases of death due to opioid toxicity (1 January 199831 December 2002). Findings: Ventricular hypertrophy was present in 5.9% of cases and severe coronary artery atherosclerosis in 5.7%. Severe coronary pathology was more pronounced among older cases. Pre-existing bronchopneumonia was present in 13.2% of cases. Hepatic pathology was the most common type of pathology, and was far more marked among older cases. Cirrhosis was present in 25.3% of those aged > 44 years. Levels of renal pathology were comparatively low, but were related significantly to increasing age. Systemic disease in more than one organ system was present in 24.4% of cases, and was related to increasing age (44% of those aged > 44 years). The only pathology for which gender was an independent predictor among opioid cases was ventricular hypertrophy, more common in males. Conclusions: Systemic disease, most prominently liver disease, is common among fatal opioid toxicity cases, and may be a factor in understanding the dynamics and age demographics of opioid-related death. (Author' s abstract)
Affiliation :
National Drug and Alcohol Research Centre, University of New South Wales, NSW, 2052,
Australie. Australia.
Australie. Australia.