Historique
Périodique
The genetic epidemiology of cannabis use, abuse and dependence
(L'épidémiologie génétique de l'usage, l'abus et la dépendance au cannabis.)
Auteur(s) :
AGRAWAL, A. ;
LYNSKEY, M. T.
Année
2006
Page(s) :
801-812
Langue(s) :
Anglais
Refs biblio. :
87
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
CANNABIS
;
ETIOLOGIE
;
FACTEUR DE VULNERABILITE
;
GENETIQUE
;
HEREDITE
;
EPIDEMIOLOGIE
Note générale :
Addiction, 2006, 101, (6), 801-812
Note de contenu :
tabl.
Résumé :
ENGLISH :
Aims: The genetic etiology of cannabis use, abuse and dependence has elicited significant interest from genetic epidemiologists. Methods: Genetically informative studies, including family, twin and adoption studies that have examined the role of genetic and environmental influences on the various stages of cannabis involvement, and the genetic relationship between cannabis, licit drugs and other hard drugs, are reviewed. Results: Findings across a number of such studies have indicated that there is a genetic basis to each stage of cannabis involvement although a proportion of the genetic factors influencing individual stages may be specific to that stage. Multivariate analyses that explore the association between cannabis and licit (alcohol and tobacco) as well as hard drugs (e.g. cocaine, opioids), using multiple methodological strategies, suggest the role of common genetic and environmental influences influencing the liability to cannabis and other drug involvement. Conclusions: The substantial evidence for the heritability of cannabis use, abuse and dependence underscore the importance of linkage and association studies that aim to find genes of etiologic significance. (Author' s abstract)
Affiliation :
Washington Univ. School of Medicine, Dprt of Psychiatry, 660 S. Euclid, Box 8134, St Louis, MO 63110. Email : arpanawustl.edu
Etats-Unis. United States.
Etats-Unis. United States.