Historique
Périodique
Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studies
(Comorbidité psychiatrique et trajectoire d'usage de la drogue chez des jumeaux mâles adultes : implications pour la conception d'études génétiques)
Auteur(s) :
TODOROV, A. A. ;
LYNSKEY, M. T. ;
GRANT, J. D. ;
SCHERRER, J. F. ;
TODD, R. D. ;
BUCHOLZ, K. K.
Année
2006
Page(s) :
948-961
Langue(s) :
Anglais
Refs biblio. :
66
Domaine :
Plusieurs produits / Several products
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
PSYCHIATRIE
;
COMORBIDITE
;
CONSOMMATION
;
TRAJECTOIRE
;
FRATRIE
;
RECHERCHE
;
GENETIQUE
Note générale :
Addictive Behaviors, 2006, 31, (6), 948-961, tabl.
Résumé :
Psychiatric comorbidity with drug dependence has been widely documented. In the present study, we reanalyze DSM-III-R diagnostic data on middle-aged male twin pairs from the VETR study using latent class methods. We identify four subtypes based on 15 diagnostic categories. We then show that these subtypes are strongly associated with differential rates of transitions in drug use histories, with increased risks in relatives for depression, alcohol, drug and ASPD, as well as with a variety of non-normative and deviant behaviors in youth and in adulthood. We use the result of these analyses to show how the use of a particular drug disorder phenotype for selecting cases could impact final sample composition. (Editor's abstract.)
Affiliation :
Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134 St. Louis, MO 63110-1502.
Etats-Unis. United States.
Etats-Unis. United States.