Historique
Périodique
Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study
(Méthadone versus buprénorphine chez des femmes enceintes dépendantes : une étude comparative en double aveugle.) une pilote prospective randomisée en double aveugle
Auteur(s) :
FISCHER, G. ;
ORTNER, R. ;
ROHRMEISTER, K. ;
JAGSCH, R. ;
BAEWERT, A. ;
LANGER, M. ;
ASCHAUER, H.
Année
2006
Page(s) :
275-281
Langue(s) :
Anglais
Refs biblio. :
33
Domaine :
Autres substances / Other substances ; Drogues illicites / Illicit drugs
Thésaurus mots-clés
METHADONE
;
BUPRENORPHINE
;
GROSSESSE
;
OBSERVANCE DU TRAITEMENT
;
RETENTION
;
ABSTINENCE
;
SYNDROME DE SEVRAGE
;
COMPARAISON
Note générale :
Addiction, 2006, 101, (2), 275-281, tabl.
Résumé :
Aims: To evaluate the efficacy and safety of methadone versus buprenorphine treatment in pregnant opioid-dependent women. Design: Randomized, double-dummy, double-blind, flexible-dosing comparison study. Setting: Addiction Clinic at the Medical University of Vienna, Austria. Participants: Eighteen women were assigned randomly to receive either methadone (n = 9) or buprenorphine (n = 9) during weeks 2429 of pregnancy. After dropouts, data were available from 14 cases (six in the methadone and eight in the buprenorphine group). Intervention: Sublingual buprenorphine tablets (824 mg/day) or oral methadone solution (40100 mg/day), with matched placebos. Measurements: Mothers: retention in treatment, urine toxicology and nicotine use. Neonates: Routine birth data, neonatal abstinence syndrome (NAS) in severity and duration. Findings: There was somewhat greater retention in the buprenorphine group but significantly lowered use of additional opioids in the methadone group (P = 0.047).Neonates: There was earlier onset of NAS in neonates born to the methadone (mean 60 hours) than to the buprenorphine groups (mean 72 hours after last medication); 43% did not require NAS-treatment with short treatment duration in both groups (mean 5 days). Conclusion: This preliminary study had limited power to detect differences but the trends observed suggest this kind of research is practicable and that further studies are warranted. (Review' s abstract)
Affiliation :
Addiction Clinic, Department of Psychiatry, Medical University of Vienna, Währinger Gürtel 1820, 1090 Vienna,
Australie. Australia.
Australie. Australia.