Historique
Périodique
Effects on smoking cessation : naltrexone combined with a cognitive behavioral treatment based on the community reinforcement approach
(Combinaison de naltrexone et d'une thérapie comportementalo-cognitive basée sur une approche de renforcement communautaire : effets sur l'arrêt du tabac)
Auteur(s) :
ROOZEN H. G. ;
VAN BEERS, S. E. C. ;
WEEVERS H. J. A. ;
BRETELER, M. H. M. ;
WILLEMSEN, M. C. ;
POSTMUS P. E. ;
KERKHOF A. J. F. M.
Année
2006
Page(s) :
45-60
Langue(s) :
Anglais
Refs biblio. :
35
Domaine :
Tabac / Tobacco / e-cigarette
Thésaurus mots-clés
SEVRAGE
;
ARRET DU TABAC
;
TABAC
;
THERAPIE COGNITIVO-COMPORTEMENTALE
;
RENFORCEMENT
;
COMPORTEMENTALISME
;
PHARMACOTHERAPIE
;
NALTREXONE
;
COMPULSION
Note générale :
Substance Use and Misuse, 2006, 41, (1), 45-60
Note de contenu :
tabl. ; graph.
Résumé :
ENGLISH :
A promising option in substance abuse treatment is the Community Reinforcement Approach (CRA). The opioid antagonist naltrexone (NTX) may work in combination with nicotine replacement therapy (NRT) to block the effects of smoking stimuli in abstinent smokers. Effects of lower doses than 50 mg/dd. have not been reported. A study was conducted in Amsterdam in 2000/2001 with the objective to explore the effects of the combination NTX (25/50-mg dd.), NRT, and CRA in terms of craving and abstinence. In a randomized open label, 2 * 2 between subjects design, 25 recovered spontaneous pneumothorax (SP) participants received 8 weeks of treatment. Due to side effects, only 3 participants were compliant in the 50-mg NTX condition. Craving significantly declined between each measurement and there was a significant interaction between decline in craving and craving measured at baseline. The abstinence rate in the CRA group was nearly double that in the non-psychosocial therapy group (46% vs. 25%; NS) at 3 months follow-up after treatment. (Editor's abstract.)
Affiliation :
Novadic-Kentron, Network for Addiction Treatment Services, Streuvelslaan 18, 4707 CH Roosendaal. E-mail : hendrik.roozennovadic-kentron.nl
Pays-Bas. Netherlands.
Pays-Bas. Netherlands.