Historique
Périodique
An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsants
(Une revue de la pharmacothérapie du sevrage et de la dépendance alcoolique avec une attention particulière pour l'utilité des anciennes et nouvelles générations d'anticonvulsifs)
Auteur(s) :
AIT-DAOUD, N. ;
MALCOLM, R. J. ;
JOHNSON, B. A.
Année
2006
Page(s) :
1628-1649
Langue(s) :
Anglais
Refs biblio. :
88
Domaine :
Alcool / Alcohol
Thésaurus mots-clés
PHARMACOTHERAPIE
;
ALCOOL
;
SEVRAGE
;
DEPENDANCE
;
MEDICAMENTS
;
ANTICONVULSIVANTS
;
EVOLUTION
;
EFFICACITE
Note générale :
Addictive Behaviors, 2006, 31, (9), 1628-1649
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
There is a growing interest in the development of new pharmacological tools for treating alcohol withdrawal and dependence. A number of anticonvulsants including valproate and carbamazepine have been shown to be safe and effective alternatives to benzodiazepines for treating alcohol withdrawal. These agents are relatively safe, are free from demonstrated abuse liability, and do not usually potentiate the psychomotor and cognitive effects of alcohol. For the treatment of alcohol dependence, there is a growing literature on the utility of medications that have neurochemical effects at opioid, serotonergic, GABAergic, and glutamate receptors. Furthermore, as a class of medication, there appears to be a growing interest in investigating the utility of novel anticonvulsants such as topiramate for the treatment of alcohol dependence. (Editor's abstract.)
Affiliation :
Department of Psychiatric Medicine, University of Virginia, P.O. Box 800623, Charlottesville, VA 22908-0623. E-mail : aitdaoudvirginia.edu
Etats-Unis. United States.
Etats-Unis. United States.