Auteur D. J. NUTT

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Beta-carboline binding to imidazoline receptors

S. M. HUSBAND ; R. A. GLENNON ; GORGERAT S. ; GOUGH R. ; TYACKE R. ; J. CROSBY ; D. J. NUTT ; J. W. LEWIS ; A. L. HUDSON | 2001
Périodique

A series of beta-carbolines were prepared and their affinities for imidazoline (i1, and i2) sites evaluated. Selected compounds were also examined at x2-adrenoceptors. Some of the beta-carbolines were found to bind with high affinity to i2-sites[...]

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Cannabis based medicines and cannabis dependence: A critical review of issues and evidence

A. K. SCHLAG ; C. HINDOCHA ; R. ZAFAR ; D. J. NUTT ; H. V. CURRAN | 2021
Dans Journal of Psychopharmacology (Online first 17/02/2021, 2021) Article : Périodique

Cannabis has been legalised for medical use in an ever-increasing number of countries. A growing body of scientific evidence supports the use of medical cannabis for a range of therapeutic indications. In parallel with these developments, concer[...]

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Clinical relevance of as-needed treatment with nalmefene in alcohol-dependent patients

H. J. AUBIN ; J. REIMER ; D. J. NUTT ; A. BLADSTROM ; L. TORUP ; C. FRANÇOIS ; J. CHICK | 2015
Dans European Addiction Research (Vol.21, n°3, April 2015) Article : Périodique

Nalmefene is the first drug approved for reduction of alcohol consumption. The aim of this study was to evaluate the clinical relevance of treatment with nalmefene in alcohol-dependent patients with a high drinking risk level from two randomised[...]

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Defining substance use disorders: Do we really need more than heavy use? [For debate]

J. REHM ; S. MARMET ; P. ANDERSON ; A. GUAL ; L. KRAUS ; D. J. NUTT ; R. ROOM ; A. V. SAMOKHVALOV ; E. SCAFATO ; M. TRAPENCIERIS ; R. W. WIERS ; G. GMEL | 2013
Dans Alcohol and Alcoholism (Vol.48, n°6, November-December 2013) Article : Périodique

Aims: The aim of the study was to explore whether the concept of heavy substance use over time can be used as definition of substance use disorder. Methods: Narrative review. Results: Heavy use over time clearly underlies the neurobiological[...]

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Philosophical Transactions of the Royal Society B, Vol.363, n°1507 - October 2008 - Discussion meeting issue: The neurobiology of addiction

T. W. ROBBINS, Éditeur scientifique ; B. J. EVERITT, Éditeur scientifique ; D. J. NUTT, Éditeur scientifique | 2008
Bulletin : Périodique

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Drug harms in the UK: a multicriteria decision analysis

D. J. NUTT ; L. A. KING ; L. D. PHILLIPS ; Independent Scientific Committee on Drugs | 2010
Dans Lancet (The) (Vol.376, n°9752, Nov 06, 2010) Article : Périodique

Proper assessment of the harms caused by the misuse of drugs can inform policy makers in health, policing, and social care. We aimed to apply multicriteria decision analysis (MCDA) modelling to a range of drug harms in the UK. Members of the Ind[...]

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Effects of Schedule I drug laws on neuroscience research and treatment innovation

D. J. NUTT ; L. A. KING ; D. E. NICHOLS | 2013
Dans Nature Reviews Neuroscience (Vol.14, n°8, August 2013) Article : Périodique

Many psychoactive drugs are used recreationally, particularly by young people. This use and its perceived dangers have led to many different classes of drugs being banned under national laws and international conventions. Indeed, the possession [...]

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Experienced drug users assess the relative harms and benefits of drugs: A web-based survey

R. L. CARHART-HARRIS ; D. J. NUTT | 2013
Dans Journal of Psychoactive Drugs (Vol.45, n°4, September-October 2013) Article : Périodique

A web-based survey was used to consult the opinions of experienced drug users on matters related to drug harms. We identified a rare sample of 93 drug users with personal experience with 11 different illicit drugs that are widely used in the UK.[...]

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Gamma hydroxy butyrate abuse and dependency

A. GONZALEZ ; D. J. NUTT | 2005
Dans Journal of Psychopharmacology (Vol.19, n°2, 2005) Article : Périodique

The recreational use of gamma hydroxy butyrate (GHB) has gained popularity over the last decade. GHB was initially sold as a safe body building and fat burning compound. It is now also widely abused by body builders and young ravers. GHB attract[...]

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Introduction. The neurobiology of drug addiction: new vistas

T. W. ROBBINS ; B. J. EVERITT ; D. J. NUTT | 2008
Dans Philosophical Transactions of the Royal Society B (Vol.363, n°1507, October 2008) Article : Périodique

This Royal Society Discussion Meeting, held on 25–26 February 2008, was intended to mark the enormous scientific progress that has been made in this field in the last decade or so, advances that can be measured from the time of a Frontiers Meeti[...]

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Maintenance buprenorphine for opioid users

F. D. LAW ; D. J. NUTT | 2003
Dans Lancet (The) (Vol.361, n°9358, February 22, 2003) Article : Périodique

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Popular intoxicants: what lessons can be learned from the last 40 years of alcohol and cannabis regulation?

R. WEISSENBORN ; D. J. NUTT | 2012
Dans Journal of Psychopharmacology (Vol.26, n°2, February 2012) Article : Périodique

In this paper we discuss the relative physical, psychological and social harms of the two most frequently used intoxicant drugs in the UK, namely cannabis and alcohol. Over the past 40 years, the use of both drugs has risen significantly with di[...]

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Psychedelics: From cave art to 21st-century medicine for addiction

I. A. VAMVAKOPOULOU ; D. J. NUTT | 2024
Dans European Addiction Research (Vol.30, n°5, October 2024) Article : Périodique

BACKGROUND: Psychedelic substance use in ritualistic and ceremonial settings dates back as early as 8,500 BCE. Only in recent years, from the mid-20th century, we have seen the re-emergence of psychedelics in a therapeutic setting and more speci[...]

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Relativiser les dangers des drogues, le pari risqué de David Nutt ; L'équasy - une addiction sous-estimée pouvant influencer le débat actuel sur les dangers des drogues

Z. DUBUS ; D. J. NUTT | 2023
Dans Swaps (n°104, Printemps 2023) Article : Périodique

Pour la première fois, un texte devenu culte du psychiatre anglais David Nutt est traduit en français, « Equasy - An overlooked addiction with implications for the current debate on drug harms ». David Nutt plaide pour une approche pragmatique d[...]

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Document numérique

Single chemical entity legal highs: assessing the risk for long term harm

C. B. McNABB ; B. R. RUSSELL ; D. CAPRIOLI ; D. J. NUTT ; S. GIBBONS ; J. W. DALLEY | 2012
Dans Current Drug Abuse Reviews (Vol.5, n°4, December 2012) Article : Périodique

A recent and dramatic increase in the emergence of novel psychoactive substances ('legal highs') has left many governments unable to provide a timely response to an increasing number of potentially harmful drugs now available to the public. In r[...]

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