Titre : | Cannabis and stroke: systematic appraisal of case reports (2015) |
Auteurs : | D. G. HACKAM |
Type de document : | Article : Périodique |
Dans : | Stroke (Vol.46, n°3, March 2015) |
Article en page(s) : | 852-856 |
Langues: | Anglais |
Discipline : | PAT (Pathologie organique / Organic pathology) |
Mots-clés : |
Thésaurus mots-clés ETUDE DE CAS ; CANNABIS ; CERVEAU ; APPAREIL CARDIOVASCULAIRE ; PATHOLOGIE ORGANIQUE ; FACTEUR DE RISQUE ; INFARCTUS |
Résumé : |
BACKGROUND AND PURPOSE: An increasing number of case reports link cannabis consumption to cerebrovascular events. Yet these case reports have not been scrutinized using criteria for causal inference.
METHODS: All case reports on cannabis and cerebrovascular events were retrieved. Four causality criteria were addressed: temporality, adequacy of stroke work-up, effects of rechallenge, and concomitant risk factors that could account for the cerebrovascular event. RESULTS: There were 34 case reports on 64 patients. Most cases (81%) exhibited a temporal relationship between cannabis exposure and the index event. In 70%, the evaluation was sufficiently comprehensive to exclude other sources for stroke. About a quarter (22%) of patients had another stroke after subsequent re-exposure to cannabis. Finally, half of patients (50%) had concomitant stroke risk factors, most commonly tobacco (34%) and alcohol (11%) consumption. CONCLUSIONS: Many case reports support a causal link between cannabis and cerebrovascular events. This accords well with epidemiological and mechanistic research on the cerebrovascular effects of cannabis. |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Revue de la littérature / Literature review |
Refs biblio. : | 39 |
Affiliation : |
Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada |
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