Titre : | Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers (2012) |
Auteurs : | L. RIGAL ; C. ALEXANDRE-DUBROEUCQ ; R. DE BEAUREPAIRE ; C. LE JEUNNE ; P. JAURY |
Type de document : | Article : Périodique |
Dans : | Alcohol and Alcoholism (Vol.47, n°4, July-August 2012) |
Article en page(s) : | 439-442 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BACLOFENE ; ETUDE RETROSPECTIVE ; TRAITEMENT DE MAINTENANCE ; ALCOOL ; DEPENDANCE ; ABSTINENCE ; CONSOMMATION ; EFFET SECONDAIRE ; POSOLOGIE ; EFFICACITEThésaurus géographique FRANCE |
Résumé : |
AIMS: The aim of the study was to assess the proportions of 'high-risk' drinkers' abstinent or with 'low-risk' consumption levels 1 year after the initiation of high-dose baclofen.
METHODS: This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment. RESULTS: Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day. CONCLUSION: High-dose baclofen should be tested in randomized placebo-controlled trials among high-risk drinkers. |
Domaine : | Alcool / Alcohol |
Refs biblio. : | 17 |
Affiliation : | Département de Médecine Générale, Faculté de Médecine Paris Descartes—Site Cochin, Université Paris Descartes, Paris, France |
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