Titre : | Cocaine addiction in mothers: potential effects on maternal care and infant development (2010) |
Auteurs : | L. STRATHEARN ; L. C. MAYES |
Type de document : | Article : Périodique |
Dans : | Annals of the New York Academy of Sciences (Vol.1187, February 2010) |
Article en page(s) : | 172-183 |
Langues: | Anglais |
Discipline : | PAT (Pathologie organique / Organic pathology) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; MERE ; GROSSESSE ; DEVELOPPEMENT ; CROISSANCE ; RELATION MERE ENFANT ; NEUROBIOLOGIE ; MODELE ; CERVEAU ; MECANISME D'ACTION ; FACTEUR DE VULNERABILITE |
Résumé : | Maternal cocaine addiction is a significant public health issue particularly affecting children, with high rates of reported abuse, neglect, and foster care placement. This review examines both preclinical and clinical evidence for how cocaine abuse may affect maternal care and infant development, exploring brain, behavioral, and neuroendocrine mechanisms. There is evidence that cocaine affects infant development both directly, via in utero exposure, and indirectly via alterations in maternal care. Two neural systems known to play an important role in both maternal care and cocaine addiction are the oxytocin and dopamine systems, mediating social and reward-related behaviors and stress reactivity. These same neural mechanisms may also be involved in the infant's development of vulnerability to addiction. Understanding the neuroendocrine pathways involved in maternal behavior and addiction may help facilitate earlier, more effective interventions to help substance-abusing mothers provide adequate care for their infant and perhaps prevent the intergenerational transmission of risk. |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Revue de la littérature / Literature review |
Refs biblio. : | 110 |
Affiliation : | The Meyer Center for Developmental Pediatrics, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas 77030-2399, USA |
Lien : | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.05142.x/abstract |
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