Titre : | A comparison of levomethadyl acetate, buprenorphine and methadone for opioid dependence (2000) |
Auteurs : | R. E. JOHNSON ; M. A. CHUTUAPE ; E. C. STRAIN ; S. L. WALSH ; M. L. STITZER ; G. E. BIGELOW |
Type de document : | Article : Périodique |
Dans : | New England Journal of Medicine (Vol.343, n°18, November 2, 2000) |
Article en page(s) : | 1290-1297 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés OPIACES ; BUPRENORPHINE ; METHADONE ; ENQUETE ; EVALUATION ; LAAMThésaurus géographique ROYAUME-UNI |
Résumé : |
BACKGROUND: Opioid dependence is a chronic, relapsing disorder with important public health implications.
METHODS: In a 17-week randomized study of 220 patients, we compared levomethadyl acetate (75 to 115 mg), buprenorphine (16 to 32 mg), and high-dose (60 to 100 mg) and low-dose (20 mg) methadone as treatments for opioid dependence. Levomethadyl acetate and buprenorphine were administered three times a week. Methadone was administered daily. Doses were individualized except in the group assigned to low-dose methadone. Patients with poor responses to treatment were switched to methadone. RESULTS: There were 55 patients in each group; 51 percent completed the trial. The mean (+/-SE) number of days that a patient remained in the study was significantly higher for those receiving levomethadyl acetate (89+/-6), buprenorphine (96+/-4), and high-dose methadone (105+/-4) than for those receiving low-dose methadone (70+/-4, P CONCLUSIONS: As compared with low-dose methadone, levomethadyl acetate, buprenorphine, and high-dose methadone substantially reduce the use of illicit opioids. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 48 |
Affiliation : | Royaume-Uni. United Kingdom. |
Centre Emetteur : | 13 OFDT |
Lien : | http://www.nejm.org/doi/full/10.1056/NEJM200011023431802 |
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