Titre : | Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men (2003) |
Auteurs : | K. J. MUKAMAL ; K. M. CONIGRAVE ; M. A. MITTLEMAN ; C. A. CAMARGO ; STAMPFER M. J. ; W. C. WILLETT ; RIMM E. B. |
Type de document : | Article : Périodique |
Dans : | New England Journal of Medicine (Vol.348, n°2, January 9, 2003) |
Article en page(s) : | 109-118 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés EPIDEMIOLOGIE DESCRIPTIVE ; ALCOOL ; FACTEUR DE RISQUE ; CONSOMMATION ; INFARCTUS ; SEXE MASCULINThésaurus géographique ETATS-UNIS |
Résumé : |
FRANÇAIS :
Cette étude américaine a suivi entre 1986 et 1998 38 077 hommes âgés de 40 à 75 ans au départ et professionnels de santé. Les hommes qui ont consommé 3 ou 4 fois par semaine ont couru seulement 68% des risques d'infarctus de ceux qui ont bu moins d'une fois par semaine. C'est plus la régularité de la consommation modérée que le type d'alcool ou la quantité qui a eu un effet protecteur sur la maladie cardiovasculaire. Néanmoins, ceux qui ont consommé plus de 2 verres par jour n'en ont pas tiré d'effet bénéfique supplémentaire. Le type de boisson et le repas n'ont pas eu d'influence. ENGLISH : BACKGROUND: Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear. METHODS: We studied the association of alcohol consumption with the risk of myocardial infarction among 38,077 male health professionals who were free of cardiovascular disease and cancer at base line. We assessed the consumption of beer, red wine, white wine, and liquor individually every four years using validated food-frequency questionnaires. We documented cases of nonfatal myocardial infarction and fatal coronary heart disease from 1986 to 1998. RESULTS: During 12 years of follow-up, there were 1418 cases of myocardial infarction. As compared with men who consumed alcohol less than once per week, men who consumed alcohol three to four or five to seven days per week had decreased risks of myocardial infarction (multivariate relative risk, 0. 68 [95 percent confidence interval, 0.55 to 0.84] and 0.63 [95 percent confidence interval, 0.54 to 0.74], respectively). The risk was similar among men who consumed less than 10 g of alcohol per drinking day and those who consumed 30 g or more. No single type of beverage conferred additional benefit, nor did consumption with meals. A 12.5-g increase in daily alcohol consumption over a four-year follow-up period was associated with a relative risk of myocardial infarction of 0.78 (95 percent confidence interval, 0. 62 to 0.99). CONCLUSIONS: Among men, consumption of alcohol at least three to four days per week was inversely associated with the risk of myocardial infarction. Neither the type of beverage nor the proportion consumed with meals substantially altered this association. Men who increased their alcohol consumption by a moderate amount during follow-up had a decreased risk of myocardial infarction. |
Domaine : | Alcool / Alcohol |
Refs biblio. : | 37 |
Affiliation : | Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA |
Centre Emetteur : | 13 OFDT |
Lien : | http://dx.doi.org/10.1056/NEJMoa022095 |
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