Titre : | Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial |
Titre traduit : | (Efficacité du disulfiram et d'une thérapie cognitivo-comportementale chez des patients en ambulatoire dépendants de la cocaïne : un essai randomisé contrôlé par placebo) |
Auteurs : | K. M. CARROLL ; L. R. FENTON ; S. A. BALL ; C. NICH ; T. L. FRANKFORTER ; SHI J. ; B. J. ROUNSAVILLE |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 264-272 |
Note générale : |
Archives of General Psychiatry, 2004, 61, (3), 264-272 |
Langues: | Français |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; PLACEBO ; ANTABUSE ; THERAPIE COGNITIVO-COMPORTEMENTALE ; EFFICACITE ; TRAITEMENT ; ALCOOLThésaurus géographique ETATS-UNIS |
Résumé : |
ENGLISH : CONTEXT: Disulfiram has emerged as a promising treatment for cocaine dependence, but it has not yet been evaluated in general populations of cocaine users. OBJECTIVES: To compare the effectiveness of disulfiram therapy with that of a placebo condition in reducing cocaine use and to compare the effectiveness of 2 active behavioral therapies-cognitive behavior therapy (CBT) and interpersonal psychotherapy (IPT)-in reducing cocaine use. DESIGN: Randomized, placebo-controlled, double-masked (for medication condition), factorial (2 x 2) trial with 4 treatment conditions: disulfiram plus CBT, disulfiram plus IPT, placebo plus CBT, and placebo plus IPT. SETTING: A community-based outpatient substance abuse treatment program. PATIENTS: A total of 121 individuals meeting the criteria for current cocaine dependence. INTERVENTIONS: Patients received either disulfiram (250 mg/d) or placebo in identical capsules. Medication compliance was monitored using a riboflavin marker procedure. Both behavioral therapies (CBT and IPT) were manual guided and were delivered in individual sessions for 12 weeks. MAIN OUTCOME MEASURES: Random regression analyses of self-reported frequency of cocaine use and results of urine toxicology screens. RESULTS: Participants assigned to disulfiram reduced their cocaine use significantly more than those assigned to placebo, and those assigned to CBT reduced their cocaine use significantly more than those assigned to IPT (P<.01 for both findings were consistent across all study samples intention to treat treatment initiators and completers benefits of disulfiram use cbt most pronounced participants who not alcohol dependent at baseline or fully abstained from drinking during treatment. adverse effects experienced by received mild considerably different those placebo. conclusions: are effective therapies general populations cocaine-dependent individuals. seems exert a direct effect on cocaine rather than through reducing concurrent use.> |
Domaine : | Plusieurs produits / Several products |
Refs biblio. : | 56 |
Affiliation : |
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516. Email : kathleen.carroll@yale.edu Etats-Unis. United States. |
Numéro Toxibase : | 1301584 |
Centre Emetteur : | 13 OFDT |
Cote : | A02759 |
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