Titre : | An open-label pilot study of risperidone in the treatment of methamphetamine dependence (2007) |
Titre traduit : | (Etude pilote non masquée de Rispéridone dans le traitement de la dépendance à la méthamphétamine) |
Auteurs : | C. W. MEREDITH ; JAFFE C. ; YANASAK E. ; CHERRIER M. ; A. J. SAXON |
Type de document : | Article : Périodique |
Dans : | Journal of Psychoactive Drugs (Vol.39 n°2, 2007) |
Article en page(s) : | 167-172 |
Note générale : |
Journal of Psychoactive Drugs, 2007, 39, (2), 167-172 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés METHAMPHETAMINE ; TRAITEMENT ; EVALUATION ; AMPHETAMINES |
Résumé : |
ENGLISH : Psychopharmacological treatments for methamphetamine (MA) dependence have questionable efficacy. Open-label risperidone was evaluated in veterans seeking MA dependence treatment. Participants (N=11) received four weeks of risperidone. They provided weekly self-reports of substance use, urine drug screens, and adverse effects. Neuropsychological assessments and psychiatric symptomatology (Brief Symptom Inventory; BSI) were measured at baseline and follow-up. The eight completers had an average risperidone dose of 3.6mg/day and decreased days of MA use during the trial from a mean of 13.0 (SD = 6.5) in the 30 days prior to starting risperidone to a mean of 0.125 (SD = 0.4; = 5.7, p = .001). When measured over time, fine motor function (Grooved Peg Board Dominant Hand) was the only neuropsychological domain to improve significantly. No other domain changed significantly from baseline to follow-up among study completers. BSI data were converted to demographically corrected T-scores utilizing appropriate normative data (mean = 50, SD = 10). BSI somatization T-scores declined from a mean of 59.0 (SD = 8.4) to 51.8 (SD = 8.3; t= 2.7, p <.05 and positive symptom distress declined from a mean of to t="3.0," p risperidone was well tolerated associated with decreased ma use. s abstract> |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 46 |
Affiliation : | Etats-Unis. United States. |
Numéro Toxibase : | 1302079 |
Centre Emetteur : | 13 OFDT |
Cote : | Abonnement |
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