Titre : | Determination of a newly encountered designer drug "p-methoxyethylamphetamine" and its metabolites in human urine and blood |
Auteurs : | K. ZAITSU ; KATAGI M. ; KAMATA T. ; KAMATA H. ; SHIMA N. ; TSUCHIHASHI H. ; HAYASHI T. ; KUROKI H. ; MATOBA R. |
Type de document : | Périodique |
Année de publication : | 2008 |
Format : | 77-84 |
Note générale : |
Forensic Science International, 2008, 177, (1), 77-84 |
Langues: | Français |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés URINE ; SANG ; DROGUES DE SYNTHESE ; ANALYSE CHIMIQUE ; DEPISTAGE ; TOXICOLOGIE ; MEDECINE LEGALE ; METHODEThésaurus géographique JAPON |
Résumé : |
ENGLISH : A newly synthesized designer drug, para-methoxyethylamphetamine (PMEA) was unexpectedly detected in the postmortem specimens of fatality involving drug intoxication in 2005, Japan. For unequivocal identification, the isomeric discrimination of PMEA and its positional-isomers was performed by GC/MS with the trifluoroacetylation. In order to prove the intake of PMEA, the characteristic metabolites of PMEA were also identified by GUMS analysis of the urine specimen with trifluoroacetylation. As a result, para-methoxyamphetamine, para-hydroxyethylamphetamine (POHEA) and para-hydroxyamphetamine were identified as the major metabolites of PMEA. For the quantitative analyses of PMEA and its three metabolites in body fluids, an automated column-switching LC/MS procedure was developed, and applied to the postmortem blood and urine specimens. In this fatal case, blood concentration of PMEA was estimated to be 12.2 ug/mL and this level seemed extremely high in comparison with lethal blood-levels of its analogues, representing acute-intoxication of the victim. Based on the quantitative results, PMEA was found to be extensively metabolized to POHEA via O-demethylation, partly followed by its conjugation. (c) 2007 Elsevier Ireland Ltd. All rights reserved. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 32 |
Affiliation : | Japon. Japan. |
Centre Emetteur : | 13 OFDT |
Cote : | A03625 |
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